Abstract

The concept of synergy provides a theoretical framework for movement stability resulting from the neural organization of multiple elements (digits, muscles, etc.) that all contribute to salient performance variables. Although stability of performance is obviously important for steady-state tasks leading to high synergy indices, a feed-forward drop in synergy indices is seen in preparation to a quick action (i.e., anticipatory synergy adjustments, ASAs). We review recent studies of multi-finger and multi-muscle synergies that show decreased indices of synergies and ASAs in patients with Parkinson's disease (PD) or multisystem atrophy. In PD, the impairments in synergies and ASAs are partially reversed by dopaminergic drugs, and changes in synergy indices are present even in PD patients at earliest diagnosis. Taken together, these results point at subcortical structures that are crucial for proper control of movement stability. It is timely to introduce the concept of impaired control of stability as an objective, quantifiable, and theory-based clinical descriptor of movement disorders that can increase our understanding of the neural control of movement with all of its implications for clinical practice.

Original languageEnglish (US)
Pages (from-to)39-48
Number of pages10
JournalNeuroscience
Volume301
DOIs
StatePublished - Aug 1 2015

Fingerprint

Parkinson Disease
Multiple System Atrophy
Muscles
Dopamine Agents
Movement Disorders
Fingers
Early Diagnosis

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

@article{61d4c9c43ca04d5db5198914e5346879,
title = "Neural control of movement stability: Lessons from studies of neurological patients",
abstract = "The concept of synergy provides a theoretical framework for movement stability resulting from the neural organization of multiple elements (digits, muscles, etc.) that all contribute to salient performance variables. Although stability of performance is obviously important for steady-state tasks leading to high synergy indices, a feed-forward drop in synergy indices is seen in preparation to a quick action (i.e., anticipatory synergy adjustments, ASAs). We review recent studies of multi-finger and multi-muscle synergies that show decreased indices of synergies and ASAs in patients with Parkinson's disease (PD) or multisystem atrophy. In PD, the impairments in synergies and ASAs are partially reversed by dopaminergic drugs, and changes in synergy indices are present even in PD patients at earliest diagnosis. Taken together, these results point at subcortical structures that are crucial for proper control of movement stability. It is timely to introduce the concept of impaired control of stability as an objective, quantifiable, and theory-based clinical descriptor of movement disorders that can increase our understanding of the neural control of movement with all of its implications for clinical practice.",
author = "Latash, {M. L.} and X. Huang",
year = "2015",
month = "8",
day = "1",
doi = "10.1016/j.neuroscience.2015.05.075",
language = "English (US)",
volume = "301",
pages = "39--48",
journal = "Neuroscience",
issn = "0306-4522",
publisher = "Elsevier Limited",

}

Neural control of movement stability : Lessons from studies of neurological patients. / Latash, M. L.; Huang, X.

In: Neuroscience, Vol. 301, 01.08.2015, p. 39-48.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Neural control of movement stability

T2 - Lessons from studies of neurological patients

AU - Latash, M. L.

AU - Huang, X.

PY - 2015/8/1

Y1 - 2015/8/1

N2 - The concept of synergy provides a theoretical framework for movement stability resulting from the neural organization of multiple elements (digits, muscles, etc.) that all contribute to salient performance variables. Although stability of performance is obviously important for steady-state tasks leading to high synergy indices, a feed-forward drop in synergy indices is seen in preparation to a quick action (i.e., anticipatory synergy adjustments, ASAs). We review recent studies of multi-finger and multi-muscle synergies that show decreased indices of synergies and ASAs in patients with Parkinson's disease (PD) or multisystem atrophy. In PD, the impairments in synergies and ASAs are partially reversed by dopaminergic drugs, and changes in synergy indices are present even in PD patients at earliest diagnosis. Taken together, these results point at subcortical structures that are crucial for proper control of movement stability. It is timely to introduce the concept of impaired control of stability as an objective, quantifiable, and theory-based clinical descriptor of movement disorders that can increase our understanding of the neural control of movement with all of its implications for clinical practice.

AB - The concept of synergy provides a theoretical framework for movement stability resulting from the neural organization of multiple elements (digits, muscles, etc.) that all contribute to salient performance variables. Although stability of performance is obviously important for steady-state tasks leading to high synergy indices, a feed-forward drop in synergy indices is seen in preparation to a quick action (i.e., anticipatory synergy adjustments, ASAs). We review recent studies of multi-finger and multi-muscle synergies that show decreased indices of synergies and ASAs in patients with Parkinson's disease (PD) or multisystem atrophy. In PD, the impairments in synergies and ASAs are partially reversed by dopaminergic drugs, and changes in synergy indices are present even in PD patients at earliest diagnosis. Taken together, these results point at subcortical structures that are crucial for proper control of movement stability. It is timely to introduce the concept of impaired control of stability as an objective, quantifiable, and theory-based clinical descriptor of movement disorders that can increase our understanding of the neural control of movement with all of its implications for clinical practice.

UR - http://www.scopus.com/inward/record.url?scp=84931292136&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84931292136&partnerID=8YFLogxK

U2 - 10.1016/j.neuroscience.2015.05.075

DO - 10.1016/j.neuroscience.2015.05.075

M3 - Review article

C2 - 26047732

AN - SCOPUS:84931292136

VL - 301

SP - 39

EP - 48

JO - Neuroscience

JF - Neuroscience

SN - 0306-4522

ER -