TY - JOUR
T1 - Neural Stem Cells Direct Axon Guidance via Their Radial Fiber Scaffold
AU - Kaur, Navjot
AU - Han, Wenqi
AU - Li, Zhuo
AU - Madrigal, M. Pilar
AU - Shim, Sungbo
AU - Pochareddy, Sirisha
AU - Gulden, Forrest O.
AU - Li, Mingfeng
AU - Xu, Xuming
AU - Xing, Xiaojun
AU - Takeo, Yutaka
AU - Li, Zhen
AU - Lu, Kangrong
AU - Imamura Kawasawa, Yuka
AU - Ballester-Lurbe, Begoña
AU - Moreno-Bravo, Juan Antonio
AU - Chédotal, Alain
AU - Terrado, José
AU - Pérez-Roger, Ignacio
AU - Koleske, Anthony J.
AU - Sestan, Nenad
N1 - Funding Information:
We thank Joshua Corbin, Kenneth Campbell, and Nicoletta Kessaris for providing mice. This work was supported by Labex LifeSenses grants ANR-10-LABX-65 and ANR-11-IDEX-0004-02 to A.C.; MINECO SAF2013-49176-C2-1-R and Programa Santander-FUSP to I.P.-R. and J.T.; NIH grants R01 MH115939 , NS105640 , and NS089662 to A.J.K.; and NIH grants MH103339 , MH106934 , MH110926 , and MH109904 to N.S. Additional support was provided by the Kavli Foundation and the Simons Foundation . We thank the Yale Macaque Brain Resource (grant to Alvaro Duque and Lynn D. Selemon, National Institute of Mental Health [NIMH] 5R01MH113257-02 ) for the Aperio CS2 scanner.
Funding Information:
We thank Joshua Corbin, Kenneth Campbell, and Nicoletta Kessaris for providing mice. This work was supported by Labex LifeSenses grants ANR-10-LABX-65 and ANR-11-IDEX-0004-02 to A.C.; MINECO SAF2013-49176-C2-1-R and Programa Santander-FUSP to I.P.-R. and J.T.; NIH grants R01 MH115939, NS105640, and NS089662 to A.J.K.; and NIH grants MH103339, MH106934, MH110926, and MH109904 to N.S. Additional support was provided by the Kavli Foundation and the Simons Foundation. We thank the Yale Macaque Brain Resource (grant to Alvaro Duque and Lynn D. Selemon, National Institute of Mental Health [NIMH] 5R01MH113257-02) for the Aperio CS2 scanner. Conceptualized & Designed Study, W.H. N.K. I.P.-R. and N.S.; Performed Experiments, W.H. N.K. S.S. S.P. M.P.M. B.B.-L. J.A.M.-B. Y.T. Zhuo Li, Zhen Li, K.L. and Y.I.K.; Generated KO Mice, W.H. Xiaojun Xing, and K.L.; Analyzed Sequencing Data, M.L. Xuming Xu, and Zhen Li; Analyzed Results, N.S. I.P.-R. N.K. and Zhuo Li; Wrote Manuscript, N.K. F.O.G. N.S. and W.H.; Edited Manuscript, all authors; Provided Resources & Funding, J.T. A.C. I.P.-R. A.J.K. and N.S.; Provided Funding & Supervision, N.S. The authors declare no competing interests.
Publisher Copyright:
© 2020 Elsevier Inc.
PY - 2020/9/23
Y1 - 2020/9/23
N2 - Kaur et al. show that the radial glial scaffold of neural stem cells from medial ganglionic eminence directs corticospinal and other axons through a previously unknown choice point at the striatopallidal junction in an RND3/ARHGAP35-dependent manner. Within corticospinal neurons, FEZF2-dependent Rnd3 expression regulates dendritic spinogenesis, axon elongation, and pontine midline crossing.
AB - Kaur et al. show that the radial glial scaffold of neural stem cells from medial ganglionic eminence directs corticospinal and other axons through a previously unknown choice point at the striatopallidal junction in an RND3/ARHGAP35-dependent manner. Within corticospinal neurons, FEZF2-dependent Rnd3 expression regulates dendritic spinogenesis, axon elongation, and pontine midline crossing.
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UR - http://www.scopus.com/inward/citedby.url?scp=85089288235&partnerID=8YFLogxK
U2 - 10.1016/j.neuron.2020.06.035
DO - 10.1016/j.neuron.2020.06.035
M3 - Article
C2 - 32707082
AN - SCOPUS:85089288235
SN - 0896-6273
VL - 107
SP - 1197-1211.e9
JO - Neuron
JF - Neuron
IS - 6
ER -