Neural substrates of the interaction of emotional stimulus processing and motor inhibitory control: An emotional linguistic go/no-go fMRI study

Martin Goldstein, Gary Brendel, Oliver Tuescher, Hong Pan, Jane Epstein, Manfred Beutel, Yihong Yang, Katherine Thomas, Kenneth Levy, Michael Silverman, Jonathon Clarkin, Michael Posner, Otto Kernberg, Emily Stern, David Silbersweig

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

Neural substrates of behavioral inhibitory control have been probed in a variety of animal model, physiologic, behavioral, and imaging studies, many emphasizing the role of prefrontal circuits. Likewise, the neurocircuitry of emotion has been investigated from a variety of perspectives. Recently, neural mechanisms mediating the interaction of emotion and behavioral regulation have become the focus of intense study. To further define neurocircuitry specifically underlying the interaction between emotional processing and response inhibition, we developed an emotional linguistic go/no-go fMRI paradigm with a factorial block design which joins explicit inhibitory task demand (i.e., go or no-go) with task-unrelated incidental emotional stimulus valence manipulation, to probe the modulation of the former by the latter. In this study of normal subjects focusing on negative emotional processing, we hypothesized activity changes in specific frontal neocortical and limbic regions reflecting modulation of response inhibition by negative stimulus processing. We observed common fronto-limbic activations (including orbitofrontal cortical and amygdalar components) associated with the interaction of emotional stimulus processing and response suppression. Further, we found a distributed cortico-limbic network to be a candidate neural substrate for the interaction of negative valence-specific processing and inhibitory task demand. These findings have implications for elucidating neural mechanisms of emotional modulation of behavioral control, with relevance to a variety of neuropsychiatric disease states marked by behavioral dysregulation within the context of negative emotional processing.

Original languageEnglish (US)
Pages (from-to)1026-1040
Number of pages15
JournalNeuroImage
Volume36
Issue number3
DOIs
StatePublished - Jul 1 2007

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Linguistics
Emotions
Magnetic Resonance Imaging
Animal Models
Inhibition (Psychology)

All Science Journal Classification (ASJC) codes

  • Neurology
  • Cognitive Neuroscience

Cite this

Goldstein, Martin ; Brendel, Gary ; Tuescher, Oliver ; Pan, Hong ; Epstein, Jane ; Beutel, Manfred ; Yang, Yihong ; Thomas, Katherine ; Levy, Kenneth ; Silverman, Michael ; Clarkin, Jonathon ; Posner, Michael ; Kernberg, Otto ; Stern, Emily ; Silbersweig, David. / Neural substrates of the interaction of emotional stimulus processing and motor inhibitory control : An emotional linguistic go/no-go fMRI study. In: NeuroImage. 2007 ; Vol. 36, No. 3. pp. 1026-1040.
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abstract = "Neural substrates of behavioral inhibitory control have been probed in a variety of animal model, physiologic, behavioral, and imaging studies, many emphasizing the role of prefrontal circuits. Likewise, the neurocircuitry of emotion has been investigated from a variety of perspectives. Recently, neural mechanisms mediating the interaction of emotion and behavioral regulation have become the focus of intense study. To further define neurocircuitry specifically underlying the interaction between emotional processing and response inhibition, we developed an emotional linguistic go/no-go fMRI paradigm with a factorial block design which joins explicit inhibitory task demand (i.e., go or no-go) with task-unrelated incidental emotional stimulus valence manipulation, to probe the modulation of the former by the latter. In this study of normal subjects focusing on negative emotional processing, we hypothesized activity changes in specific frontal neocortical and limbic regions reflecting modulation of response inhibition by negative stimulus processing. We observed common fronto-limbic activations (including orbitofrontal cortical and amygdalar components) associated with the interaction of emotional stimulus processing and response suppression. Further, we found a distributed cortico-limbic network to be a candidate neural substrate for the interaction of negative valence-specific processing and inhibitory task demand. These findings have implications for elucidating neural mechanisms of emotional modulation of behavioral control, with relevance to a variety of neuropsychiatric disease states marked by behavioral dysregulation within the context of negative emotional processing.",
author = "Martin Goldstein and Gary Brendel and Oliver Tuescher and Hong Pan and Jane Epstein and Manfred Beutel and Yihong Yang and Katherine Thomas and Kenneth Levy and Michael Silverman and Jonathon Clarkin and Michael Posner and Otto Kernberg and Emily Stern and David Silbersweig",
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Goldstein, M, Brendel, G, Tuescher, O, Pan, H, Epstein, J, Beutel, M, Yang, Y, Thomas, K, Levy, K, Silverman, M, Clarkin, J, Posner, M, Kernberg, O, Stern, E & Silbersweig, D 2007, 'Neural substrates of the interaction of emotional stimulus processing and motor inhibitory control: An emotional linguistic go/no-go fMRI study', NeuroImage, vol. 36, no. 3, pp. 1026-1040. https://doi.org/10.1016/j.neuroimage.2007.01.056

Neural substrates of the interaction of emotional stimulus processing and motor inhibitory control : An emotional linguistic go/no-go fMRI study. / Goldstein, Martin; Brendel, Gary; Tuescher, Oliver; Pan, Hong; Epstein, Jane; Beutel, Manfred; Yang, Yihong; Thomas, Katherine; Levy, Kenneth; Silverman, Michael; Clarkin, Jonathon; Posner, Michael; Kernberg, Otto; Stern, Emily; Silbersweig, David.

In: NeuroImage, Vol. 36, No. 3, 01.07.2007, p. 1026-1040.

Research output: Contribution to journalArticle

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AU - Goldstein, Martin

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AU - Pan, Hong

AU - Epstein, Jane

AU - Beutel, Manfred

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AU - Thomas, Katherine

AU - Levy, Kenneth

AU - Silverman, Michael

AU - Clarkin, Jonathon

AU - Posner, Michael

AU - Kernberg, Otto

AU - Stern, Emily

AU - Silbersweig, David

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