Neural tube defects are rare among black Americans but not in sub-Saharan black Africans: The case of Yaounde - Cameroon

A. K. Njamnshi, V. de P. Djientcheu, Alain Zingraff Lekoubou Looti, M. Guemse, M. T. Obama, R. Mbu, S. Takongmo, I. Kago

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Background: Neural tube defects (NTD) are complex malformations rare in black Americans and Japanese. The incidence related to births or community based studies have not been published in Cameroon or in black sub-Saharan countries, except one study in the Nigerian middle belt [A. Courtney, Adolfo Correa Rowland, Janet D. Cragan and Alverson J. Clinton, Are encephalocede neural tube defects? Official journal of the American Academy of paediatrics 2006; (13): 1-10.]. Methods: To evaluate the incidence of neural tube defects in Yaounde, the birth record of the maternities was retrospectively exploited during the last ten years period (1997-2006). Results: A total of 52,710 births were recorded in the 03 main hospitals of Yaounde. Ninety eight (98) cases of NTD with an incidence of 1.99 cases per 1000 births were registered. Spina bifida cystica (myelomeningocele, meningocele) represented 71%, followed by encephalocele (21.1%) and anencephaly (5.4%). Periconceptional folic acid was not taken by any of the mothers in our study. Abortion of affected pregnancies is illegal in Cameroon. Conclusion: Neural Tube Defects may not be so rare in sub-Saharan black Africans particularly in Yaounde (Cameroon). Spina bifida is the most frequent malformation. The results of this study make a case for periconceptional folic acid supplementation in our communities. The respective contributions of racial (genetic) versus environmental (or nutritional) factors will however have to be studied in order to develop a comprehensive prevention strategy.

Original languageEnglish (US)
Pages (from-to)13-17
Number of pages5
JournalJournal of the neurological sciences
Volume270
Issue number1-2
DOIs
StatePublished - Jul 15 2008

Fingerprint

Cameroon
Neural Tube Defects
Parturition
Folic Acid
Incidence
Spina Bifida Cystica
Anencephaly
Encephalocele
Birth Certificates
Meningomyelocele
Spinal Dysraphism
Mothers
Pediatrics
Pregnancy

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Njamnshi, A. K. ; Djientcheu, V. de P. ; Lekoubou Looti, Alain Zingraff ; Guemse, M. ; Obama, M. T. ; Mbu, R. ; Takongmo, S. ; Kago, I. / Neural tube defects are rare among black Americans but not in sub-Saharan black Africans : The case of Yaounde - Cameroon. In: Journal of the neurological sciences. 2008 ; Vol. 270, No. 1-2. pp. 13-17.
@article{0931427927aa435a9009bbe91117f50e,
title = "Neural tube defects are rare among black Americans but not in sub-Saharan black Africans: The case of Yaounde - Cameroon",
abstract = "Background: Neural tube defects (NTD) are complex malformations rare in black Americans and Japanese. The incidence related to births or community based studies have not been published in Cameroon or in black sub-Saharan countries, except one study in the Nigerian middle belt [A. Courtney, Adolfo Correa Rowland, Janet D. Cragan and Alverson J. Clinton, Are encephalocede neural tube defects? Official journal of the American Academy of paediatrics 2006; (13): 1-10.]. Methods: To evaluate the incidence of neural tube defects in Yaounde, the birth record of the maternities was retrospectively exploited during the last ten years period (1997-2006). Results: A total of 52,710 births were recorded in the 03 main hospitals of Yaounde. Ninety eight (98) cases of NTD with an incidence of 1.99 cases per 1000 births were registered. Spina bifida cystica (myelomeningocele, meningocele) represented 71{\%}, followed by encephalocele (21.1{\%}) and anencephaly (5.4{\%}). Periconceptional folic acid was not taken by any of the mothers in our study. Abortion of affected pregnancies is illegal in Cameroon. Conclusion: Neural Tube Defects may not be so rare in sub-Saharan black Africans particularly in Yaounde (Cameroon). Spina bifida is the most frequent malformation. The results of this study make a case for periconceptional folic acid supplementation in our communities. The respective contributions of racial (genetic) versus environmental (or nutritional) factors will however have to be studied in order to develop a comprehensive prevention strategy.",
author = "Njamnshi, {A. K.} and Djientcheu, {V. de P.} and {Lekoubou Looti}, {Alain Zingraff} and M. Guemse and Obama, {M. T.} and R. Mbu and S. Takongmo and I. Kago",
year = "2008",
month = "7",
day = "15",
doi = "10.1016/j.jns.2008.01.010",
language = "English (US)",
volume = "270",
pages = "13--17",
journal = "Journal of the Neurological Sciences",
issn = "0022-510X",
publisher = "Elsevier",
number = "1-2",

}

Neural tube defects are rare among black Americans but not in sub-Saharan black Africans : The case of Yaounde - Cameroon. / Njamnshi, A. K.; Djientcheu, V. de P.; Lekoubou Looti, Alain Zingraff; Guemse, M.; Obama, M. T.; Mbu, R.; Takongmo, S.; Kago, I.

In: Journal of the neurological sciences, Vol. 270, No. 1-2, 15.07.2008, p. 13-17.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Neural tube defects are rare among black Americans but not in sub-Saharan black Africans

T2 - The case of Yaounde - Cameroon

AU - Njamnshi, A. K.

AU - Djientcheu, V. de P.

AU - Lekoubou Looti, Alain Zingraff

AU - Guemse, M.

AU - Obama, M. T.

AU - Mbu, R.

AU - Takongmo, S.

AU - Kago, I.

PY - 2008/7/15

Y1 - 2008/7/15

N2 - Background: Neural tube defects (NTD) are complex malformations rare in black Americans and Japanese. The incidence related to births or community based studies have not been published in Cameroon or in black sub-Saharan countries, except one study in the Nigerian middle belt [A. Courtney, Adolfo Correa Rowland, Janet D. Cragan and Alverson J. Clinton, Are encephalocede neural tube defects? Official journal of the American Academy of paediatrics 2006; (13): 1-10.]. Methods: To evaluate the incidence of neural tube defects in Yaounde, the birth record of the maternities was retrospectively exploited during the last ten years period (1997-2006). Results: A total of 52,710 births were recorded in the 03 main hospitals of Yaounde. Ninety eight (98) cases of NTD with an incidence of 1.99 cases per 1000 births were registered. Spina bifida cystica (myelomeningocele, meningocele) represented 71%, followed by encephalocele (21.1%) and anencephaly (5.4%). Periconceptional folic acid was not taken by any of the mothers in our study. Abortion of affected pregnancies is illegal in Cameroon. Conclusion: Neural Tube Defects may not be so rare in sub-Saharan black Africans particularly in Yaounde (Cameroon). Spina bifida is the most frequent malformation. The results of this study make a case for periconceptional folic acid supplementation in our communities. The respective contributions of racial (genetic) versus environmental (or nutritional) factors will however have to be studied in order to develop a comprehensive prevention strategy.

AB - Background: Neural tube defects (NTD) are complex malformations rare in black Americans and Japanese. The incidence related to births or community based studies have not been published in Cameroon or in black sub-Saharan countries, except one study in the Nigerian middle belt [A. Courtney, Adolfo Correa Rowland, Janet D. Cragan and Alverson J. Clinton, Are encephalocede neural tube defects? Official journal of the American Academy of paediatrics 2006; (13): 1-10.]. Methods: To evaluate the incidence of neural tube defects in Yaounde, the birth record of the maternities was retrospectively exploited during the last ten years period (1997-2006). Results: A total of 52,710 births were recorded in the 03 main hospitals of Yaounde. Ninety eight (98) cases of NTD with an incidence of 1.99 cases per 1000 births were registered. Spina bifida cystica (myelomeningocele, meningocele) represented 71%, followed by encephalocele (21.1%) and anencephaly (5.4%). Periconceptional folic acid was not taken by any of the mothers in our study. Abortion of affected pregnancies is illegal in Cameroon. Conclusion: Neural Tube Defects may not be so rare in sub-Saharan black Africans particularly in Yaounde (Cameroon). Spina bifida is the most frequent malformation. The results of this study make a case for periconceptional folic acid supplementation in our communities. The respective contributions of racial (genetic) versus environmental (or nutritional) factors will however have to be studied in order to develop a comprehensive prevention strategy.

UR - http://www.scopus.com/inward/record.url?scp=44649107690&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=44649107690&partnerID=8YFLogxK

U2 - 10.1016/j.jns.2008.01.010

DO - 10.1016/j.jns.2008.01.010

M3 - Article

C2 - 18295800

AN - SCOPUS:44649107690

VL - 270

SP - 13

EP - 17

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

SN - 0022-510X

IS - 1-2

ER -