Neurobehavioral performance in young adults living on a 28-h day for 6 weeks

Jung H. Lee, Wei Wang, Edward J. Silva, Anne Marie Chang, Karine D. Scheuermaier, Sean W. Cain, Jeanne F. Duffy

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Objectives: Performance on many cognitive tasks varies with time awake and with circadian phase, and the forced desynchrony (FD) protocol can be used to separate these influences on performance. Some performance tasks show practice effects, whereas the Psychomotor Vigilance Task (PVT) has been reported not to show such effects. We aimed to compare performance on the PVT and on an addition test (ADD) across a 6-week FD study, to determine whether practice effects were present and to analyze the circadian and wakedependent modulation of the 2 measures. Design and Setting: A 47-day FD study conducted at the Brigham and Women's Hospital General Clinical Research Center. Participants: Eleven healthy adults (mean age: 24.4 years, 2 women). Measurements and Results: For 2 baseline days and across 6 weeks of FD, we gave a test battery (ADD, PVT, self-rating of effort and performance) every 2 hours. During FD, there was a significant (P < 0.0001) improvement in ADD performance (more correct calculations completed), whereas PVT performance (mean reaction time, fastest 10% reaction times, lapses) significantly (P < 0.0001) declined week by week. Subjective ratings of PVT performance indicated that subjects felt their performance improved across the study (P < 0.0001), but their rating of whether they could have performed better with greater effort did not change across the study (P > 0.05). Conclusions: The decline in PVT performance suggests a cumulative effect of sleep loss across the 6-week study. Subjects did not accurately detect their declining PVT performance, and a motivational factor could not explain this decline.

Original languageEnglish (US)
Pages (from-to)905-913
Number of pages9
JournalSleep
Volume32
Issue number7
DOIs
StatePublished - Jul 1 2009

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Task Performance and Analysis
Young Adult
Psychomotor Performance
General Hospitals
Healthy Volunteers
Sleep
Research

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Physiology (medical)

Cite this

Lee, J. H., Wang, W., Silva, E. J., Chang, A. M., Scheuermaier, K. D., Cain, S. W., & Duffy, J. F. (2009). Neurobehavioral performance in young adults living on a 28-h day for 6 weeks. Sleep, 32(7), 905-913. https://doi.org/10.1093/sleep/32.7.905
Lee, Jung H. ; Wang, Wei ; Silva, Edward J. ; Chang, Anne Marie ; Scheuermaier, Karine D. ; Cain, Sean W. ; Duffy, Jeanne F. / Neurobehavioral performance in young adults living on a 28-h day for 6 weeks. In: Sleep. 2009 ; Vol. 32, No. 7. pp. 905-913.
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Lee, JH, Wang, W, Silva, EJ, Chang, AM, Scheuermaier, KD, Cain, SW & Duffy, JF 2009, 'Neurobehavioral performance in young adults living on a 28-h day for 6 weeks', Sleep, vol. 32, no. 7, pp. 905-913. https://doi.org/10.1093/sleep/32.7.905

Neurobehavioral performance in young adults living on a 28-h day for 6 weeks. / Lee, Jung H.; Wang, Wei; Silva, Edward J.; Chang, Anne Marie; Scheuermaier, Karine D.; Cain, Sean W.; Duffy, Jeanne F.

In: Sleep, Vol. 32, No. 7, 01.07.2009, p. 905-913.

Research output: Contribution to journalArticle

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AU - Cain, Sean W.

AU - Duffy, Jeanne F.

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N2 - Objectives: Performance on many cognitive tasks varies with time awake and with circadian phase, and the forced desynchrony (FD) protocol can be used to separate these influences on performance. Some performance tasks show practice effects, whereas the Psychomotor Vigilance Task (PVT) has been reported not to show such effects. We aimed to compare performance on the PVT and on an addition test (ADD) across a 6-week FD study, to determine whether practice effects were present and to analyze the circadian and wakedependent modulation of the 2 measures. Design and Setting: A 47-day FD study conducted at the Brigham and Women's Hospital General Clinical Research Center. Participants: Eleven healthy adults (mean age: 24.4 years, 2 women). Measurements and Results: For 2 baseline days and across 6 weeks of FD, we gave a test battery (ADD, PVT, self-rating of effort and performance) every 2 hours. During FD, there was a significant (P < 0.0001) improvement in ADD performance (more correct calculations completed), whereas PVT performance (mean reaction time, fastest 10% reaction times, lapses) significantly (P < 0.0001) declined week by week. Subjective ratings of PVT performance indicated that subjects felt their performance improved across the study (P < 0.0001), but their rating of whether they could have performed better with greater effort did not change across the study (P > 0.05). Conclusions: The decline in PVT performance suggests a cumulative effect of sleep loss across the 6-week study. Subjects did not accurately detect their declining PVT performance, and a motivational factor could not explain this decline.

AB - Objectives: Performance on many cognitive tasks varies with time awake and with circadian phase, and the forced desynchrony (FD) protocol can be used to separate these influences on performance. Some performance tasks show practice effects, whereas the Psychomotor Vigilance Task (PVT) has been reported not to show such effects. We aimed to compare performance on the PVT and on an addition test (ADD) across a 6-week FD study, to determine whether practice effects were present and to analyze the circadian and wakedependent modulation of the 2 measures. Design and Setting: A 47-day FD study conducted at the Brigham and Women's Hospital General Clinical Research Center. Participants: Eleven healthy adults (mean age: 24.4 years, 2 women). Measurements and Results: For 2 baseline days and across 6 weeks of FD, we gave a test battery (ADD, PVT, self-rating of effort and performance) every 2 hours. During FD, there was a significant (P < 0.0001) improvement in ADD performance (more correct calculations completed), whereas PVT performance (mean reaction time, fastest 10% reaction times, lapses) significantly (P < 0.0001) declined week by week. Subjective ratings of PVT performance indicated that subjects felt their performance improved across the study (P < 0.0001), but their rating of whether they could have performed better with greater effort did not change across the study (P > 0.05). Conclusions: The decline in PVT performance suggests a cumulative effect of sleep loss across the 6-week study. Subjects did not accurately detect their declining PVT performance, and a motivational factor could not explain this decline.

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Lee JH, Wang W, Silva EJ, Chang AM, Scheuermaier KD, Cain SW et al. Neurobehavioral performance in young adults living on a 28-h day for 6 weeks. Sleep. 2009 Jul 1;32(7):905-913. https://doi.org/10.1093/sleep/32.7.905