Neurobiology of hypoxic-ischemic injury in the developing brain

Michael V. Johnston, William H. Trescher, Akira Ishida, Wako Nakajima, Alvin Zipursky

Research output: Contribution to journalReview article

351 Citations (Scopus)

Abstract

Hypoxic ischemia is a common cause of damage to the fetal and neonatal brain. Although systemic and cerebrovascular physiologic factors play an important role in the initial phases of hypoxic-ischemic injuries, the intrinsic vulnerability of specific cell types and systems in the developing brain may be more important in determining the final pattern of damage and functional disability, Excitotoxicity, a term applied to the death of neurons and certain other cells caused by overstimulation of excitatory, mainly glutamate, neurotransmitter receptors, plays a critical role in these processes. Selected neuronal circuits as well as certain populations of glia such as immature periventricular oligodendroglia may die from excitotoxicity triggered by hypoxic ischemia. These patterns of neuropathologic vulnerability are associated with clinical syndromes of neurologic disability such as the extrapyramidal and spastic diplegia forms of cerebral palsy. The cascade of biochemical and histopathologic events triggered by hypoxic ischemia can extend for days to weeks after the insult is triggered, creating the potential for therapeutic interventions.

Original languageEnglish (US)
Pages (from-to)735-741
Number of pages7
JournalPediatric Research
Volume49
Issue number6
StatePublished - Jun 21 2001

Fingerprint

Neurobiology
Ischemia
Wounds and Injuries
Brain
Neurotransmitter Receptor
Oligodendroglia
Glutamate Receptors
Neuroglia
Nervous System
Neurons
Population
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health

Cite this

Johnston, M. V., Trescher, W. H., Ishida, A., Nakajima, W., & Zipursky, A. (2001). Neurobiology of hypoxic-ischemic injury in the developing brain. Pediatric Research, 49(6), 735-741.
Johnston, Michael V. ; Trescher, William H. ; Ishida, Akira ; Nakajima, Wako ; Zipursky, Alvin. / Neurobiology of hypoxic-ischemic injury in the developing brain. In: Pediatric Research. 2001 ; Vol. 49, No. 6. pp. 735-741.
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Johnston, MV, Trescher, WH, Ishida, A, Nakajima, W & Zipursky, A 2001, 'Neurobiology of hypoxic-ischemic injury in the developing brain', Pediatric Research, vol. 49, no. 6, pp. 735-741.

Neurobiology of hypoxic-ischemic injury in the developing brain. / Johnston, Michael V.; Trescher, William H.; Ishida, Akira; Nakajima, Wako; Zipursky, Alvin.

In: Pediatric Research, Vol. 49, No. 6, 21.06.2001, p. 735-741.

Research output: Contribution to journalReview article

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AU - Johnston, Michael V.

AU - Trescher, William H.

AU - Ishida, Akira

AU - Nakajima, Wako

AU - Zipursky, Alvin

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Johnston MV, Trescher WH, Ishida A, Nakajima W, Zipursky A. Neurobiology of hypoxic-ischemic injury in the developing brain. Pediatric Research. 2001 Jun 21;49(6):735-741.