Neurocognitive dysfunction in hematopoietic cell transplant recipients: Expert review from the late effects and Quality of Life Working Committee of the CIBMTR and complications and Quality of Life Working Party of the EBMT

David Buchbinder, Debra Lynch Kelly, Rafael F. Duarte, Jeffery J. Auletta, Neel Bhatt, Michael Byrne, Zachariah Defilipp, Melissa Gabriel, Anuj Mahindra, Maxim Norkin, Helene Schoemans, Ami J. Shah, Ibrahim Ahmed, Yoshiko Atsuta, Grzegorz W. Basak, Sara Beattie, Sita Bhella, Christopher Bredeson, Nancy Bunin, Jignesh DalalAndrew Daly, James Gajewski, Robert Peter Gale, John Galvin, Mehdi Hamadani, Robert J. Hayashi, Kehinde Adekola, Jason Law, Catherine J. Lee, Jane Liesveld, Adriana K. Malone, Arnon Nagler, Seema Naik, Taiga Nishihori, Susan K. Parsons, Angela Scherwath, Hannah Lise Schofield, Robert Soiffer, Jeff Szer, Ida Twist, Anne B. Warwick, Baldeep Wirk, Jean Yi, Minoo Battiwalla, Mary D.E. Flowers, Bipin Savani, Bronwen E. Shaw

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Hematopoietic cell transplantation (HCT) is a potentially curative treatment for children and adults with malignant and non-malignant diseases. Despite increasing survival rates, long-term morbidity following HCT is substantial. Neurocognitive dysfunction is a serious cause of morbidity, yet little is known about neurocognitive dysfunction following HCT. To address this gap, collaborative efforts of the Center for International Blood and Marrow Transplant Research and the European Society for Blood and Marrow Transplantation undertook an expert review of neurocognitive dysfunction following HCT. In this review, we define what constitutes neurocognitive dysfunction, characterize its risk factors and sequelae, describe tools and methods to assess neurocognitive function in HCT recipients, and discuss possible interventions for HCT patients with this condition. This review aims to help clinicians understand the scope of this health-related problem, highlight its impact on well-being of survivors, and to help determine factors that may improve identification of patients at risk for declines in cognitive functioning after HCT. In particular, we review strategies for preventing and treating neurocognitive dysfunction in HCT patients. Lastly, we highlight the need for well-designed studies to develop and test interventions aimed at preventing and improving neurocognitive dysfunction and its sequelae following HCT.

Original languageEnglish (US)
Pages (from-to)535-555
Number of pages21
JournalBone Marrow Transplantation
Volume53
Issue number5
DOIs
StatePublished - May 1 2018

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Cell Transplantation
Quality of Life
Transplants
Bone Marrow
Morbidity
Transplant Recipients
Survivors
Survival Rate
Transplantation
Health

All Science Journal Classification (ASJC) codes

  • Hematology
  • Transplantation

Cite this

Buchbinder, David ; Kelly, Debra Lynch ; Duarte, Rafael F. ; Auletta, Jeffery J. ; Bhatt, Neel ; Byrne, Michael ; Defilipp, Zachariah ; Gabriel, Melissa ; Mahindra, Anuj ; Norkin, Maxim ; Schoemans, Helene ; Shah, Ami J. ; Ahmed, Ibrahim ; Atsuta, Yoshiko ; Basak, Grzegorz W. ; Beattie, Sara ; Bhella, Sita ; Bredeson, Christopher ; Bunin, Nancy ; Dalal, Jignesh ; Daly, Andrew ; Gajewski, James ; Gale, Robert Peter ; Galvin, John ; Hamadani, Mehdi ; Hayashi, Robert J. ; Adekola, Kehinde ; Law, Jason ; Lee, Catherine J. ; Liesveld, Jane ; Malone, Adriana K. ; Nagler, Arnon ; Naik, Seema ; Nishihori, Taiga ; Parsons, Susan K. ; Scherwath, Angela ; Schofield, Hannah Lise ; Soiffer, Robert ; Szer, Jeff ; Twist, Ida ; Warwick, Anne B. ; Wirk, Baldeep ; Yi, Jean ; Battiwalla, Minoo ; Flowers, Mary D.E. ; Savani, Bipin ; Shaw, Bronwen E. / Neurocognitive dysfunction in hematopoietic cell transplant recipients : Expert review from the late effects and Quality of Life Working Committee of the CIBMTR and complications and Quality of Life Working Party of the EBMT. In: Bone Marrow Transplantation. 2018 ; Vol. 53, No. 5. pp. 535-555.
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title = "Neurocognitive dysfunction in hematopoietic cell transplant recipients: Expert review from the late effects and Quality of Life Working Committee of the CIBMTR and complications and Quality of Life Working Party of the EBMT",
abstract = "Hematopoietic cell transplantation (HCT) is a potentially curative treatment for children and adults with malignant and non-malignant diseases. Despite increasing survival rates, long-term morbidity following HCT is substantial. Neurocognitive dysfunction is a serious cause of morbidity, yet little is known about neurocognitive dysfunction following HCT. To address this gap, collaborative efforts of the Center for International Blood and Marrow Transplant Research and the European Society for Blood and Marrow Transplantation undertook an expert review of neurocognitive dysfunction following HCT. In this review, we define what constitutes neurocognitive dysfunction, characterize its risk factors and sequelae, describe tools and methods to assess neurocognitive function in HCT recipients, and discuss possible interventions for HCT patients with this condition. This review aims to help clinicians understand the scope of this health-related problem, highlight its impact on well-being of survivors, and to help determine factors that may improve identification of patients at risk for declines in cognitive functioning after HCT. In particular, we review strategies for preventing and treating neurocognitive dysfunction in HCT patients. Lastly, we highlight the need for well-designed studies to develop and test interventions aimed at preventing and improving neurocognitive dysfunction and its sequelae following HCT.",
author = "David Buchbinder and Kelly, {Debra Lynch} and Duarte, {Rafael F.} and Auletta, {Jeffery J.} and Neel Bhatt and Michael Byrne and Zachariah Defilipp and Melissa Gabriel and Anuj Mahindra and Maxim Norkin and Helene Schoemans and Shah, {Ami J.} and Ibrahim Ahmed and Yoshiko Atsuta and Basak, {Grzegorz W.} and Sara Beattie and Sita Bhella and Christopher Bredeson and Nancy Bunin and Jignesh Dalal and Andrew Daly and James Gajewski and Gale, {Robert Peter} and John Galvin and Mehdi Hamadani and Hayashi, {Robert J.} and Kehinde Adekola and Jason Law and Lee, {Catherine J.} and Jane Liesveld and Malone, {Adriana K.} and Arnon Nagler and Seema Naik and Taiga Nishihori and Parsons, {Susan K.} and Angela Scherwath and Schofield, {Hannah Lise} and Robert Soiffer and Jeff Szer and Ida Twist and Warwick, {Anne B.} and Baldeep Wirk and Jean Yi and Minoo Battiwalla and Flowers, {Mary D.E.} and Bipin Savani and Shaw, {Bronwen E.}",
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language = "English (US)",
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Buchbinder, D, Kelly, DL, Duarte, RF, Auletta, JJ, Bhatt, N, Byrne, M, Defilipp, Z, Gabriel, M, Mahindra, A, Norkin, M, Schoemans, H, Shah, AJ, Ahmed, I, Atsuta, Y, Basak, GW, Beattie, S, Bhella, S, Bredeson, C, Bunin, N, Dalal, J, Daly, A, Gajewski, J, Gale, RP, Galvin, J, Hamadani, M, Hayashi, RJ, Adekola, K, Law, J, Lee, CJ, Liesveld, J, Malone, AK, Nagler, A, Naik, S, Nishihori, T, Parsons, SK, Scherwath, A, Schofield, HL, Soiffer, R, Szer, J, Twist, I, Warwick, AB, Wirk, B, Yi, J, Battiwalla, M, Flowers, MDE, Savani, B & Shaw, BE 2018, 'Neurocognitive dysfunction in hematopoietic cell transplant recipients: Expert review from the late effects and Quality of Life Working Committee of the CIBMTR and complications and Quality of Life Working Party of the EBMT', Bone Marrow Transplantation, vol. 53, no. 5, pp. 535-555. https://doi.org/10.1038/s41409-017-0055-7

Neurocognitive dysfunction in hematopoietic cell transplant recipients : Expert review from the late effects and Quality of Life Working Committee of the CIBMTR and complications and Quality of Life Working Party of the EBMT. / Buchbinder, David; Kelly, Debra Lynch; Duarte, Rafael F.; Auletta, Jeffery J.; Bhatt, Neel; Byrne, Michael; Defilipp, Zachariah; Gabriel, Melissa; Mahindra, Anuj; Norkin, Maxim; Schoemans, Helene; Shah, Ami J.; Ahmed, Ibrahim; Atsuta, Yoshiko; Basak, Grzegorz W.; Beattie, Sara; Bhella, Sita; Bredeson, Christopher; Bunin, Nancy; Dalal, Jignesh; Daly, Andrew; Gajewski, James; Gale, Robert Peter; Galvin, John; Hamadani, Mehdi; Hayashi, Robert J.; Adekola, Kehinde; Law, Jason; Lee, Catherine J.; Liesveld, Jane; Malone, Adriana K.; Nagler, Arnon; Naik, Seema; Nishihori, Taiga; Parsons, Susan K.; Scherwath, Angela; Schofield, Hannah Lise; Soiffer, Robert; Szer, Jeff; Twist, Ida; Warwick, Anne B.; Wirk, Baldeep; Yi, Jean; Battiwalla, Minoo; Flowers, Mary D.E.; Savani, Bipin; Shaw, Bronwen E.

In: Bone Marrow Transplantation, Vol. 53, No. 5, 01.05.2018, p. 535-555.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Neurocognitive dysfunction in hematopoietic cell transplant recipients

T2 - Expert review from the late effects and Quality of Life Working Committee of the CIBMTR and complications and Quality of Life Working Party of the EBMT

AU - Buchbinder, David

AU - Kelly, Debra Lynch

AU - Duarte, Rafael F.

AU - Auletta, Jeffery J.

AU - Bhatt, Neel

AU - Byrne, Michael

AU - Defilipp, Zachariah

AU - Gabriel, Melissa

AU - Mahindra, Anuj

AU - Norkin, Maxim

AU - Schoemans, Helene

AU - Shah, Ami J.

AU - Ahmed, Ibrahim

AU - Atsuta, Yoshiko

AU - Basak, Grzegorz W.

AU - Beattie, Sara

AU - Bhella, Sita

AU - Bredeson, Christopher

AU - Bunin, Nancy

AU - Dalal, Jignesh

AU - Daly, Andrew

AU - Gajewski, James

AU - Gale, Robert Peter

AU - Galvin, John

AU - Hamadani, Mehdi

AU - Hayashi, Robert J.

AU - Adekola, Kehinde

AU - Law, Jason

AU - Lee, Catherine J.

AU - Liesveld, Jane

AU - Malone, Adriana K.

AU - Nagler, Arnon

AU - Naik, Seema

AU - Nishihori, Taiga

AU - Parsons, Susan K.

AU - Scherwath, Angela

AU - Schofield, Hannah Lise

AU - Soiffer, Robert

AU - Szer, Jeff

AU - Twist, Ida

AU - Warwick, Anne B.

AU - Wirk, Baldeep

AU - Yi, Jean

AU - Battiwalla, Minoo

AU - Flowers, Mary D.E.

AU - Savani, Bipin

AU - Shaw, Bronwen E.

PY - 2018/5/1

Y1 - 2018/5/1

N2 - Hematopoietic cell transplantation (HCT) is a potentially curative treatment for children and adults with malignant and non-malignant diseases. Despite increasing survival rates, long-term morbidity following HCT is substantial. Neurocognitive dysfunction is a serious cause of morbidity, yet little is known about neurocognitive dysfunction following HCT. To address this gap, collaborative efforts of the Center for International Blood and Marrow Transplant Research and the European Society for Blood and Marrow Transplantation undertook an expert review of neurocognitive dysfunction following HCT. In this review, we define what constitutes neurocognitive dysfunction, characterize its risk factors and sequelae, describe tools and methods to assess neurocognitive function in HCT recipients, and discuss possible interventions for HCT patients with this condition. This review aims to help clinicians understand the scope of this health-related problem, highlight its impact on well-being of survivors, and to help determine factors that may improve identification of patients at risk for declines in cognitive functioning after HCT. In particular, we review strategies for preventing and treating neurocognitive dysfunction in HCT patients. Lastly, we highlight the need for well-designed studies to develop and test interventions aimed at preventing and improving neurocognitive dysfunction and its sequelae following HCT.

AB - Hematopoietic cell transplantation (HCT) is a potentially curative treatment for children and adults with malignant and non-malignant diseases. Despite increasing survival rates, long-term morbidity following HCT is substantial. Neurocognitive dysfunction is a serious cause of morbidity, yet little is known about neurocognitive dysfunction following HCT. To address this gap, collaborative efforts of the Center for International Blood and Marrow Transplant Research and the European Society for Blood and Marrow Transplantation undertook an expert review of neurocognitive dysfunction following HCT. In this review, we define what constitutes neurocognitive dysfunction, characterize its risk factors and sequelae, describe tools and methods to assess neurocognitive function in HCT recipients, and discuss possible interventions for HCT patients with this condition. This review aims to help clinicians understand the scope of this health-related problem, highlight its impact on well-being of survivors, and to help determine factors that may improve identification of patients at risk for declines in cognitive functioning after HCT. In particular, we review strategies for preventing and treating neurocognitive dysfunction in HCT patients. Lastly, we highlight the need for well-designed studies to develop and test interventions aimed at preventing and improving neurocognitive dysfunction and its sequelae following HCT.

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U2 - 10.1038/s41409-017-0055-7

DO - 10.1038/s41409-017-0055-7

M3 - Review article

C2 - 29343837

AN - SCOPUS:85040684681

VL - 53

SP - 535

EP - 555

JO - Bone Marrow Transplantation

JF - Bone Marrow Transplantation

SN - 0268-3369

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