@article{654a13e42d70447e8950fd66a9eabdb8,
title = "Neurocognitive dysfunction in hematopoietic cell transplant recipients: Expert review from the late effects and Quality of Life Working Committee of the CIBMTR and complications and Quality of Life Working Party of the EBMT",
abstract = "Hematopoietic cell transplantation (HCT) is a potentially curative treatment for children and adults with malignant and non-malignant diseases. Despite increasing survival rates, long-term morbidity following HCT is substantial. Neurocognitive dysfunction is a serious cause of morbidity, yet little is known about neurocognitive dysfunction following HCT. To address this gap, collaborative efforts of the Center for International Blood and Marrow Transplant Research and the European Society for Blood and Marrow Transplantation undertook an expert review of neurocognitive dysfunction following HCT. In this review, we define what constitutes neurocognitive dysfunction, characterize its risk factors and sequelae, describe tools and methods to assess neurocognitive function in HCT recipients, and discuss possible interventions for HCT patients with this condition. This review aims to help clinicians understand the scope of this health-related problem, highlight its impact on well-being of survivors, and to help determine factors that may improve identification of patients at risk for declines in cognitive functioning after HCT. In particular, we review strategies for preventing and treating neurocognitive dysfunction in HCT patients. Lastly, we highlight the need for well-designed studies to develop and test interventions aimed at preventing and improving neurocognitive dysfunction and its sequelae following HCT.",
author = "David Buchbinder and Kelly, {Debra Lynch} and Duarte, {Rafael F.} and Auletta, {Jeffery J.} and Neel Bhatt and Michael Byrne and Zachariah Defilipp and Melissa Gabriel and Anuj Mahindra and Maxim Norkin and Helene Schoemans and Shah, {Ami J.} and Ibrahim Ahmed and Yoshiko Atsuta and Basak, {Grzegorz W.} and Sara Beattie and Sita Bhella and Christopher Bredeson and Nancy Bunin and Jignesh Dalal and Andrew Daly and James Gajewski and Gale, {Robert Peter} and John Galvin and Mehdi Hamadani and Hayashi, {Robert J.} and Kehinde Adekola and Jason Law and Lee, {Catherine J.} and Jane Liesveld and Malone, {Adriana K.} and Arnon Nagler and Seema Naik and Taiga Nishihori and Parsons, {Susan K.} and Angela Scherwath and Schofield, {Hannah Lise} and Robert Soiffer and Jeff Szer and Ida Twist and Warwick, {Anne B.} and Wirk, {Baldeep M.} and Jean Yi and Minoo Battiwalla and Flowers, {Mary D.E.} and Bipin Savani and Shaw, {Bronwen E.}",
note = "Funding Information: CIBMTR Support List The CIBMTR is supported primarily by Public Health Service Grant/Cooperative Agreement 5U24-CA076518 from the National Cancer Institute (NCI), the National Heart, Lung and Blood Institute (NHLBI) and the National Institute of Allergy and Infectious Diseases (NIAID); a Grant/Cooperative Agreement 5U10HL069294 from NHLBI and NCI; a contract HHSH250201200016C with Health Resources and Services Administration (HRSA/DHHS); two Grants N00014-15-1-0848 and N00014-16-1-2020. Publisher Copyright: {\textcopyright} 2017 The Author(s).",
year = "2018",
month = may,
day = "1",
doi = "10.1038/s41409-017-0055-7",
language = "English (US)",
volume = "53",
pages = "535--555",
journal = "Bone Marrow Transplantation",
issn = "0268-3369",
publisher = "Nature Publishing Group",
number = "5",
}