Neuroendocrine and Immune Contributors to Fatigue

Marni N. Silverman, Christine M. Heim, Urs M. Nater, Andrea H. Marques, Esther M. Sternberg

Research output: Contribution to journalArticle

82 Scopus citations

Abstract

Abstract: Central fatigue, a persistent and subjective sense of tiredness, generally correlates poorly with traditional markers of disease. It is frequently associated with psychosocial factors, such as depression, sleep disorder, anxiety, and coping style, which suggest that dysregulation of the body's stress systems may serve as an underlying mechanism in the maintenance of chronic fatigue (CF). This article addresses the endocrine, neural, and immune factors that contribute to fatigue and describes research regarding the role of these factors in chronic fatigue syndrome as a model for addressing the biology of CF. In general, hypoactivity of the hypothalamic-pituitary-adrenal axis, autonomic nervous system alterations characterized by sympathetic overactivity and low vagal tone, as well as immune abnormalities, may contribute to the expression of CF. Noninvasive methods for evaluating endocrine, neural, and immune function are also discussed. Simultaneous evaluation of neuroendocrine and immune systems with noninvasive techniques will help elucidate the underlying interactions of these systems, their role in disease susceptibility, and progression of stress-related disorders.

Original languageEnglish (US)
Pages (from-to)338-346
Number of pages9
JournalPM and R
Volume2
Issue number5
DOIs
StatePublished - May 1 2010

All Science Journal Classification (ASJC) codes

  • Physical Therapy, Sports Therapy and Rehabilitation
  • Rehabilitation
  • Neurology
  • Clinical Neurology

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    Silverman, M. N., Heim, C. M., Nater, U. M., Marques, A. H., & Sternberg, E. M. (2010). Neuroendocrine and Immune Contributors to Fatigue. PM and R, 2(5), 338-346. https://doi.org/10.1016/j.pmrj.2010.04.008