Neurogenic obesity and systemic inflammation following spinal cord injury: A review

Gary J. Farkas, David R. Gater

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Content: Spinal Cord Injury (SCI) results in physiological changes that markedly reduces whole-body metabolism, resulting in neurogenic obesity via adipose tissue accumulation. Adipose tissue has been implicated in the release of proinflammatory adipokines that lead to chronic, systemic inflammation, and evidence suggests these adipokines contribute to the pathogeneses of metabolic diseases that often accompany obesity. In this review, we propose the concept of neurogenic obesity through paralysis-induced adiposity as the primary source of systemic inflammation and metabolic dysfunction reported in chronic SCI. We also briefly discuss how exercise in SCI can attenuate the negative consequences of obesity-induced inflammation and its comorbidities. Methods: A MEDLINE, PubMed, Google Scholar, and ClinicalKey search was performed using the following search terms: obesity, adiposity, adipose tissue, proinflammatory adipokines, proinflammatory cytokines, metabolic dysfunction, exercise, physical activity, and spinal cord injury. All papers identified were full-text, English language papers. The reference list of identified papers was also searched for additional papers. Results: Research suggests that obesity in SCI results in a state of chronic, systemic inflammation primarily through proinflammatory adipokines secreted from excess adipose tissue. The reduction of adipose tissue through the use of diet and exercise demonstrates promise to combat neurogenic obesity, inflammation, and cardiometabolic dysfunction in SCI. Conclusion: Proinflammatory adipokines may serve as biomarkers for the development of obesity-related complication in SCI. Mechanistic and interventional studies on neurogenic obesity-induced inflammation in chronic SCI are warranted.

Original languageEnglish (US)
Pages (from-to)378-387
Number of pages10
JournalJournal of Spinal Cord Medicine
Volume41
Issue number4
DOIs
StatePublished - Jul 4 2018

Fingerprint

Spinal Cord Injuries
Obesity
Inflammation
Adipokines
Adipose Tissue
Adiposity
Neurogenic Inflammation
Metabolic Diseases
PubMed
MEDLINE
Paralysis
Comorbidity
Language
Biomarkers
Cytokines
Diet
Research

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Farkas, Gary J. ; Gater, David R. / Neurogenic obesity and systemic inflammation following spinal cord injury : A review. In: Journal of Spinal Cord Medicine. 2018 ; Vol. 41, No. 4. pp. 378-387.
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abstract = "Content: Spinal Cord Injury (SCI) results in physiological changes that markedly reduces whole-body metabolism, resulting in neurogenic obesity via adipose tissue accumulation. Adipose tissue has been implicated in the release of proinflammatory adipokines that lead to chronic, systemic inflammation, and evidence suggests these adipokines contribute to the pathogeneses of metabolic diseases that often accompany obesity. In this review, we propose the concept of neurogenic obesity through paralysis-induced adiposity as the primary source of systemic inflammation and metabolic dysfunction reported in chronic SCI. We also briefly discuss how exercise in SCI can attenuate the negative consequences of obesity-induced inflammation and its comorbidities. Methods: A MEDLINE, PubMed, Google Scholar, and ClinicalKey search was performed using the following search terms: obesity, adiposity, adipose tissue, proinflammatory adipokines, proinflammatory cytokines, metabolic dysfunction, exercise, physical activity, and spinal cord injury. All papers identified were full-text, English language papers. The reference list of identified papers was also searched for additional papers. Results: Research suggests that obesity in SCI results in a state of chronic, systemic inflammation primarily through proinflammatory adipokines secreted from excess adipose tissue. The reduction of adipose tissue through the use of diet and exercise demonstrates promise to combat neurogenic obesity, inflammation, and cardiometabolic dysfunction in SCI. Conclusion: Proinflammatory adipokines may serve as biomarkers for the development of obesity-related complication in SCI. Mechanistic and interventional studies on neurogenic obesity-induced inflammation in chronic SCI are warranted.",
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Neurogenic obesity and systemic inflammation following spinal cord injury : A review. / Farkas, Gary J.; Gater, David R.

In: Journal of Spinal Cord Medicine, Vol. 41, No. 4, 04.07.2018, p. 378-387.

Research output: Contribution to journalReview article

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