Neurologic complications of acute myelomonoblastic leukemia of four years’ duration

James O. Ballard, Javad Towfighi, Robert W. Brennan, Shazadi Saleem, M. Elaine Eyster

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

An adult with acute nonlymphoblastic leukemia involving the central nervous system is presented. Unusual features included: (1) Focal signs and radiographic evidence of sagittal sinus occlusion early in the course of disease; (2) progressive meningeal, cranial nerve, and spinal nerve involvement despite a 4-year bone marrow remission; (3) intracerebral tumor formation, and (4) retrobulbar optic neuritis associated with microscopic findings of herpeslike viral particles. The incidence of clinically overt neurologic disease in adults with acute nonlymphoblastic leukemia seems to have increased in tandem with improved chemotherapy. The prophylactic treatment of the central nervous system during prolonged remission of adult acute nonlymphoblastic leukemia may prove of benefit to these patients.

Original languageEnglish (US)
Pages (from-to)174-178
Number of pages5
JournalNeurology
Volume28
Issue number2
DOIs
StatePublished - Feb 1978

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

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