Neurologic complications of radiation therapy

Nicole E. Cross, Michael Glantz

Research output: Contribution to journalReview article

84 Citations (Scopus)

Abstract

Injury to the central and peripheral nervous systems is an increasingly frequent consequence of standard radiation treatment protocols for tumors involving or adjacent to nervous system structures. Characteristic temporal, clinical, radiographic, and laboratory features distinguish a number of specific radiation injury syndromes, but meticulous and repeated evaluations over time are often required to establish a diagnosis. These syndromes vary with regard to prognosis and therapeutic options, and competing diagnoses with very different natural histories and therapies often mask or mimic the signs and symptoms of radiation-related nervous system injury. The ability to efficiently negotiate this complicated differential diagnostic landscape allows for early diagnosis of tumor recurrence or an alternative etiology, prompt institution of appropriate therapy, avoidance of unnecessary diagnostic studies, and confident prognostication for patients and families. Even after the diagnosis of a radiation-related complication is made, continued vigilance for additional sites or manifestations of radiation injury is mandatory. Meanwhile, further research into treatment, prevention, and the causes of individual susceptibility to radiation injury are essential.

Original languageEnglish (US)
Pages (from-to)249-277
Number of pages29
JournalNeurologic clinics
Volume21
Issue number1
DOIs
StatePublished - Feb 1 2003

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Radiation Injuries
Nervous System
Radiotherapy
Radiation
Nervous System Trauma
Aptitude
Peripheral Nervous System
Therapeutics
Clinical Protocols
Masks
Natural History
Signs and Symptoms
Early Diagnosis
Neoplasms
Central Nervous System
Recurrence
Wounds and Injuries
Research

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Cross, Nicole E. ; Glantz, Michael. / Neurologic complications of radiation therapy. In: Neurologic clinics. 2003 ; Vol. 21, No. 1. pp. 249-277.
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Neurologic complications of radiation therapy. / Cross, Nicole E.; Glantz, Michael.

In: Neurologic clinics, Vol. 21, No. 1, 01.02.2003, p. 249-277.

Research output: Contribution to journalReview article

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