Neurologic manifestations of intravascular coagulation in patients with cancer: A clinicopathologic analysis of 12 cases

Robert C. Collins, Hamid Al-Mondhiry, Norman L. Chernik, Jerome B. Posner

Research output: Contribution to journalArticle

56 Citations (Scopus)

Abstract

Among 1,459 autopsied patients with cancer, 12 had multifocal infarcts of the brain that appeared to be caused by intravascular coagulation. Most of these patients were women with leukemia or lymphoma, and all had a clinical course in which neurologic signs and symptoms were prominent. All had evidence of generalized brain disease (delirium and stupor or coma), and several also had focal brain disease (focal seizures, hemiparesis). All patients had laboratory evidence of coagulation abnormalities, although these were often not severe when neurologic symptoms began. Pathologically, there were multifocal hemorrhagic or ischemic infarcts in the distribution of several cerebral vessels, without a systemic source for cerebral emboli. Fibrin thrombi were identified in cerebral vessels and in vessels of several other organs. The clinical findings fit the pathologic picture, and in most instances the correct diagnosis might have been made earlier had it been considered.

Original languageEnglish (US)
Pages (from-to)795-806
Number of pages12
JournalNeurology
Volume25
Issue number9
StatePublished - Sep 1975

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Neurologic Manifestations
Brain Diseases
Intracranial Embolism
Stupor
Neoplasms
Delirium
Paresis
Coma
Fibrin
Lymphoma
Leukemia
Seizures
Thrombosis
Brain

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

Cite this

Collins, R. C., Al-Mondhiry, H., Chernik, N. L., & Posner, J. B. (1975). Neurologic manifestations of intravascular coagulation in patients with cancer: A clinicopathologic analysis of 12 cases. Neurology, 25(9), 795-806.
Collins, Robert C. ; Al-Mondhiry, Hamid ; Chernik, Norman L. ; Posner, Jerome B. / Neurologic manifestations of intravascular coagulation in patients with cancer : A clinicopathologic analysis of 12 cases. In: Neurology. 1975 ; Vol. 25, No. 9. pp. 795-806.
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Collins, RC, Al-Mondhiry, H, Chernik, NL & Posner, JB 1975, 'Neurologic manifestations of intravascular coagulation in patients with cancer: A clinicopathologic analysis of 12 cases', Neurology, vol. 25, no. 9, pp. 795-806.

Neurologic manifestations of intravascular coagulation in patients with cancer : A clinicopathologic analysis of 12 cases. / Collins, Robert C.; Al-Mondhiry, Hamid; Chernik, Norman L.; Posner, Jerome B.

In: Neurology, Vol. 25, No. 9, 09.1975, p. 795-806.

Research output: Contribution to journalArticle

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