Neurologic manifestations of intravascular coagulation in patients with cancer: A clinicopathologic analysis of 12 cases

Robert C. Collins, Hamid Al-Mondhiry, Norman L. Chernik, Jerome B. Posner

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57 Scopus citations

Abstract

Among 1,459 autopsied patients with cancer, 12 had multifocal infarcts of the brain that appeared to be caused by intravascular coagulation. Most of these patients were women with leukemia or lymphoma, and all had a clinical course in which neurologic signs and symptoms were prominent. All had evidence of generalized brain disease (delirium and stupor or coma), and several also had focal brain disease (focal seizures, hemiparesis). All patients had laboratory evidence of coagulation abnormalities, although these were often not severe when neurologic symptoms began. Pathologically, there were multifocal hemorrhagic or ischemic infarcts in the distribution of several cerebral vessels, without a systemic source for cerebral emboli. Fibrin thrombi were identified in cerebral vessels and in vessels of several other organs. The clinical findings fit the pathologic picture, and in most instances the correct diagnosis might have been made earlier had it been considered.

Original languageEnglish (US)
Pages (from-to)795-806
Number of pages12
JournalNeurology
Volume25
Issue number9
DOIs
StatePublished - Sep 1975

All Science Journal Classification (ASJC) codes

  • Clinical Neurology

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