Neurological tests and behavioral deficits in chronic thalamic and chronic decerebrate rats

H. J. Grill, Ralph Norgren

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

The taste reactivity of chronic decerebrate rats is very similar to intact rats although chronic thalamic rats display only the quinine-like rejection sequence. The performance of intact (n = 12), decerebrate (n = 10) and thalamic (n = 10) preparations was further compared across a set of simple behavior tests to more broadly assess the behavioral capacities of the rodent brain stem. Decerebrate rats were immobile. They exhibited no spontaneous activity other than grooming, but often overreacted with well-coordinated movements (i.e., running, jumping and climbing) to seemingly inappropriate activating stimuli such as tail pinch, handling or water squirted on the fur. Decerebrates had lower thresholds for elicited attack and grooming behaviors than thalamic or intact rats. The thalamic preparation exhibited a wider range of intact neurological responses than the decerebrate. Cage climbing, resistance to gravity, suspension and muscle tone reactions, rhythmic vibrissae movements and examination of object with snout and mandible were difficult to distinguish from controls. Decerebrates either did not perform these responses or did so in a clearly different manner. In contrast, grooming behavior in thalamics was much less effective than in decerebrates. Thalamic rats spontaneously executed grooming sequences, but the responses were misdirected and ineffective. Despite their relative immobility, decerebrates coordinated grooming sequences and maintained their fur. No single mechanism appears to account for the constellation of deficits and capacities observed in either chronic thalamic or chronic decerebrate rats.

Original languageEnglish (US)
Pages (from-to)299-312
Number of pages14
JournalBrain research
Volume143
Issue number2
DOIs
StatePublished - Mar 24 1978

Fingerprint

Grooming
Vibrissae
Quinine
Gravitation
Mandible
Running
Brain Stem
Tail
Rodentia
Suspensions
Muscles
Water

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

@article{99cb6512de03408aa5170fce8e33c5e7,
title = "Neurological tests and behavioral deficits in chronic thalamic and chronic decerebrate rats",
abstract = "The taste reactivity of chronic decerebrate rats is very similar to intact rats although chronic thalamic rats display only the quinine-like rejection sequence. The performance of intact (n = 12), decerebrate (n = 10) and thalamic (n = 10) preparations was further compared across a set of simple behavior tests to more broadly assess the behavioral capacities of the rodent brain stem. Decerebrate rats were immobile. They exhibited no spontaneous activity other than grooming, but often overreacted with well-coordinated movements (i.e., running, jumping and climbing) to seemingly inappropriate activating stimuli such as tail pinch, handling or water squirted on the fur. Decerebrates had lower thresholds for elicited attack and grooming behaviors than thalamic or intact rats. The thalamic preparation exhibited a wider range of intact neurological responses than the decerebrate. Cage climbing, resistance to gravity, suspension and muscle tone reactions, rhythmic vibrissae movements and examination of object with snout and mandible were difficult to distinguish from controls. Decerebrates either did not perform these responses or did so in a clearly different manner. In contrast, grooming behavior in thalamics was much less effective than in decerebrates. Thalamic rats spontaneously executed grooming sequences, but the responses were misdirected and ineffective. Despite their relative immobility, decerebrates coordinated grooming sequences and maintained their fur. No single mechanism appears to account for the constellation of deficits and capacities observed in either chronic thalamic or chronic decerebrate rats.",
author = "Grill, {H. J.} and Ralph Norgren",
year = "1978",
month = "3",
day = "24",
doi = "10.1016/0006-8993(78)90570-X",
language = "English (US)",
volume = "143",
pages = "299--312",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "2",

}

Neurological tests and behavioral deficits in chronic thalamic and chronic decerebrate rats. / Grill, H. J.; Norgren, Ralph.

In: Brain research, Vol. 143, No. 2, 24.03.1978, p. 299-312.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Neurological tests and behavioral deficits in chronic thalamic and chronic decerebrate rats

AU - Grill, H. J.

AU - Norgren, Ralph

PY - 1978/3/24

Y1 - 1978/3/24

N2 - The taste reactivity of chronic decerebrate rats is very similar to intact rats although chronic thalamic rats display only the quinine-like rejection sequence. The performance of intact (n = 12), decerebrate (n = 10) and thalamic (n = 10) preparations was further compared across a set of simple behavior tests to more broadly assess the behavioral capacities of the rodent brain stem. Decerebrate rats were immobile. They exhibited no spontaneous activity other than grooming, but often overreacted with well-coordinated movements (i.e., running, jumping and climbing) to seemingly inappropriate activating stimuli such as tail pinch, handling or water squirted on the fur. Decerebrates had lower thresholds for elicited attack and grooming behaviors than thalamic or intact rats. The thalamic preparation exhibited a wider range of intact neurological responses than the decerebrate. Cage climbing, resistance to gravity, suspension and muscle tone reactions, rhythmic vibrissae movements and examination of object with snout and mandible were difficult to distinguish from controls. Decerebrates either did not perform these responses or did so in a clearly different manner. In contrast, grooming behavior in thalamics was much less effective than in decerebrates. Thalamic rats spontaneously executed grooming sequences, but the responses were misdirected and ineffective. Despite their relative immobility, decerebrates coordinated grooming sequences and maintained their fur. No single mechanism appears to account for the constellation of deficits and capacities observed in either chronic thalamic or chronic decerebrate rats.

AB - The taste reactivity of chronic decerebrate rats is very similar to intact rats although chronic thalamic rats display only the quinine-like rejection sequence. The performance of intact (n = 12), decerebrate (n = 10) and thalamic (n = 10) preparations was further compared across a set of simple behavior tests to more broadly assess the behavioral capacities of the rodent brain stem. Decerebrate rats were immobile. They exhibited no spontaneous activity other than grooming, but often overreacted with well-coordinated movements (i.e., running, jumping and climbing) to seemingly inappropriate activating stimuli such as tail pinch, handling or water squirted on the fur. Decerebrates had lower thresholds for elicited attack and grooming behaviors than thalamic or intact rats. The thalamic preparation exhibited a wider range of intact neurological responses than the decerebrate. Cage climbing, resistance to gravity, suspension and muscle tone reactions, rhythmic vibrissae movements and examination of object with snout and mandible were difficult to distinguish from controls. Decerebrates either did not perform these responses or did so in a clearly different manner. In contrast, grooming behavior in thalamics was much less effective than in decerebrates. Thalamic rats spontaneously executed grooming sequences, but the responses were misdirected and ineffective. Despite their relative immobility, decerebrates coordinated grooming sequences and maintained their fur. No single mechanism appears to account for the constellation of deficits and capacities observed in either chronic thalamic or chronic decerebrate rats.

UR - http://www.scopus.com/inward/record.url?scp=0017887417&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0017887417&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(78)90570-X

DO - 10.1016/0006-8993(78)90570-X

M3 - Article

C2 - 630411

AN - SCOPUS:0017887417

VL - 143

SP - 299

EP - 312

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 2

ER -