Neuronal alignment on asymmetric textured surfaces

Ross Beighley, Elise Spedden, Koray Sekeroglu, Timothy Atherton, Melik C. Demirel, Cristian Staii

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Axonal growth and the formation of synaptic connections are key steps in the development of the nervous system. Here, we present experimental and theoretical results on axonal growth and interconnectivity in order to elucidate some of the basic rules that neuronal cells use for functional connections with one another. We demonstrate that a unidirectional nanotextured surface can bias axonal growth. We perform a systematic investigation of neuronal processes on asymmetric surfaces and quantify the role that biomechanical surface cues play in neuronal growth. These results represent an important step towards engineering directed axonal growth for neuro-regeneration studies.

Original languageEnglish (US)
Article number143701
JournalApplied Physics Letters
Volume101
Issue number14
DOIs
StatePublished - Oct 1 2012

All Science Journal Classification (ASJC) codes

  • Physics and Astronomy (miscellaneous)

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    Beighley, R., Spedden, E., Sekeroglu, K., Atherton, T., Demirel, M. C., & Staii, C. (2012). Neuronal alignment on asymmetric textured surfaces. Applied Physics Letters, 101(14), [143701]. https://doi.org/10.1063/1.4755837