We wished to determine if chronic neuropeptide Y (NPY) infusion (1 ng/min for 1 week by Alzet minipump) could decrease plasma renin activity (PRA) and norepinephrine (NE) in a rat myocardial infarction (MI) model of moderate compensated congestive heart failure (CHF). CHF was produced by prior (6-8 weeks) ligation of the left coronary artery; control rats were sham-operated. Carotid arterial blood was drawn for PRA and NE in conscious unrestrained rats that had been instrumented 24 h earlier. MI rats had increased PRA as compared with sham-operated rats [8.73 ± 1.27 vs. 5.10 ± 0.91 ng angiotensin (AI) I/ml·h, mean ± SE]. During chronic NPY infusion, PRA was reduced to normal in the MI group (4.78 ± 0.91) but was not affected in the sham group (5.65 ± 0.51). Plasma NE was altered similarly, but the changes did not reach statistical significance. These data suggest that NPY has the capacity to restrain renin release in moderate compensated CHF.
All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine