Neuropeptide Y Y1 receptor-mediated biodegradable photoluminescent nanobubbles as ultrasound contrast agents for targeted breast cancer imaging

Juan Li, Yuchen Tian, Dingying Shan, An Gong, Leyong Zeng, Wenzhi Ren, Lingchao Xiang, Ethan Gerhard, Jinshun Zhao, Jian Yang, Aiguo Wu

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Targeted molecular imaging has attracted great attention in cancer diagnosis and treatment. However, most clinically used ultrasound contrast agents (UCAs) are non-targeted microbubbles seldom used for cancer imaging. Here, we fabricated fluorescent nanobubbles (NBs) by encapsulation of liquid tetradecafluorohexane (C6F14) within biodegradable photoluminescent polymers (BPLPs) through an emulsion-evaporation process and conjugation of PNBL-NPY ligand for specific targeting of Y1 receptors overexpressed in breast tumors. The developed PNBL-NPY modified NBs were uniform in size with good dispersibility and photostability, presenting good ultrasound enhancement. Further, in vitro and in vivo results indicated that the fabricated NBs exhibit high affinity and specificity to Y1 receptor-overexpressing breast cancer cells and tumors with minimal toxicity and damage to organs. Our developed PNBL-NPY-modified NBs are novel targeted UCAs for safe, efficient and specific targeted breast cancer imaging, and may provide a new nanoplatform for early cancer diagnosis and treatment in the future.

Original languageEnglish (US)
Pages (from-to)106-117
Number of pages12
JournalBiomaterials
Volume116
DOIs
StatePublished - Feb 1 2017

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Contrast Media
Ultrasonics
Breast Neoplasms
Imaging techniques
Tumors
Molecular imaging
Biodegradable polymers
Emulsions
Encapsulation
Microbubbles
Molecular Imaging
Toxicity
Evaporation
Ligands
Early Detection of Cancer
Cells
Neoplasms
Polymers
Liquids
neuropeptide Y-Y1 receptor

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Cite this

Li, Juan ; Tian, Yuchen ; Shan, Dingying ; Gong, An ; Zeng, Leyong ; Ren, Wenzhi ; Xiang, Lingchao ; Gerhard, Ethan ; Zhao, Jinshun ; Yang, Jian ; Wu, Aiguo. / Neuropeptide Y Y1 receptor-mediated biodegradable photoluminescent nanobubbles as ultrasound contrast agents for targeted breast cancer imaging. In: Biomaterials. 2017 ; Vol. 116. pp. 106-117.
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Neuropeptide Y Y1 receptor-mediated biodegradable photoluminescent nanobubbles as ultrasound contrast agents for targeted breast cancer imaging. / Li, Juan; Tian, Yuchen; Shan, Dingying; Gong, An; Zeng, Leyong; Ren, Wenzhi; Xiang, Lingchao; Gerhard, Ethan; Zhao, Jinshun; Yang, Jian; Wu, Aiguo.

In: Biomaterials, Vol. 116, 01.02.2017, p. 106-117.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Neuropeptide Y Y1 receptor-mediated biodegradable photoluminescent nanobubbles as ultrasound contrast agents for targeted breast cancer imaging

AU - Li, Juan

AU - Tian, Yuchen

AU - Shan, Dingying

AU - Gong, An

AU - Zeng, Leyong

AU - Ren, Wenzhi

AU - Xiang, Lingchao

AU - Gerhard, Ethan

AU - Zhao, Jinshun

AU - Yang, Jian

AU - Wu, Aiguo

PY - 2017/2/1

Y1 - 2017/2/1

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