Neuroprotective and antiangiogenic actions of PEDF in the eye: Molecular targets and therapeutic potential

Research output: Contribution to journalReview article

176 Citations (Scopus)

Abstract

Pigment epithelium-derived factor (PEDF) is a 50-kDa protein encoded by a single gene that shows strong conservation across phyla from fish to mammals. It is secreted by the retinal pigment epithelium (RPE) and a select number of other cell types in the eye, as well as by other tissues in the body. PEDF was originally defined by its ability to induce differentiation in retinoblastoma cells. It also promotes a non-proliferative, differentiated state in a number of other cell types. PEDF protects retinal neurons from light damage, oxidative stress and glutamate excitotoxicity. PEDF is also antiangiogenic and can inhibit the growth of blood vessels in the eye induced in a variety of ways. A balance in the levels of PEDF and the proangiogenic factor vascular endothelial growth factor-A is perturbed in a range of retinal neovascular diseases. Some of the pathways by which PEDF exerts its actions on cells have now been defined. Peptide fragments of PEDF carry biological activity and may be valuable therapeutic agents that readily penetrate the eye.

Original languageEnglish (US)
Pages (from-to)561-577
Number of pages17
JournalProgress in Retinal and Eye Research
Volume23
Issue number5
DOIs
StatePublished - Sep 1 2004

Fingerprint

Therapeutics
Cell Count
Retinal Neurons
Retinal Diseases
Peptide Fragments
Retinoblastoma
Retinal Pigment Epithelium
pigment epithelium-derived factor
Vascular Endothelial Growth Factor A
Blood Vessels
Glutamic Acid
Mammals
Fishes
Oxidative Stress
Light
Growth
Genes
Proteins

All Science Journal Classification (ASJC) codes

  • Sensory Systems
  • Ophthalmology

Cite this

@article{0fd8bc40543c445c9ac9795385da6d21,
title = "Neuroprotective and antiangiogenic actions of PEDF in the eye: Molecular targets and therapeutic potential",
abstract = "Pigment epithelium-derived factor (PEDF) is a 50-kDa protein encoded by a single gene that shows strong conservation across phyla from fish to mammals. It is secreted by the retinal pigment epithelium (RPE) and a select number of other cell types in the eye, as well as by other tissues in the body. PEDF was originally defined by its ability to induce differentiation in retinoblastoma cells. It also promotes a non-proliferative, differentiated state in a number of other cell types. PEDF protects retinal neurons from light damage, oxidative stress and glutamate excitotoxicity. PEDF is also antiangiogenic and can inhibit the growth of blood vessels in the eye induced in a variety of ways. A balance in the levels of PEDF and the proangiogenic factor vascular endothelial growth factor-A is perturbed in a range of retinal neovascular diseases. Some of the pathways by which PEDF exerts its actions on cells have now been defined. Peptide fragments of PEDF carry biological activity and may be valuable therapeutic agents that readily penetrate the eye.",
author = "Colin Barnstable and Joyce Tombran-Tink",
year = "2004",
month = "9",
day = "1",
doi = "10.1016/j.preteyeres.2004.05.002",
language = "English (US)",
volume = "23",
pages = "561--577",
journal = "Progress in Retinal and Eye Research",
issn = "1350-9462",
publisher = "Elsevier Limited",
number = "5",

}

TY - JOUR

T1 - Neuroprotective and antiangiogenic actions of PEDF in the eye

T2 - Molecular targets and therapeutic potential

AU - Barnstable, Colin

AU - Tombran-Tink, Joyce

PY - 2004/9/1

Y1 - 2004/9/1

N2 - Pigment epithelium-derived factor (PEDF) is a 50-kDa protein encoded by a single gene that shows strong conservation across phyla from fish to mammals. It is secreted by the retinal pigment epithelium (RPE) and a select number of other cell types in the eye, as well as by other tissues in the body. PEDF was originally defined by its ability to induce differentiation in retinoblastoma cells. It also promotes a non-proliferative, differentiated state in a number of other cell types. PEDF protects retinal neurons from light damage, oxidative stress and glutamate excitotoxicity. PEDF is also antiangiogenic and can inhibit the growth of blood vessels in the eye induced in a variety of ways. A balance in the levels of PEDF and the proangiogenic factor vascular endothelial growth factor-A is perturbed in a range of retinal neovascular diseases. Some of the pathways by which PEDF exerts its actions on cells have now been defined. Peptide fragments of PEDF carry biological activity and may be valuable therapeutic agents that readily penetrate the eye.

AB - Pigment epithelium-derived factor (PEDF) is a 50-kDa protein encoded by a single gene that shows strong conservation across phyla from fish to mammals. It is secreted by the retinal pigment epithelium (RPE) and a select number of other cell types in the eye, as well as by other tissues in the body. PEDF was originally defined by its ability to induce differentiation in retinoblastoma cells. It also promotes a non-proliferative, differentiated state in a number of other cell types. PEDF protects retinal neurons from light damage, oxidative stress and glutamate excitotoxicity. PEDF is also antiangiogenic and can inhibit the growth of blood vessels in the eye induced in a variety of ways. A balance in the levels of PEDF and the proangiogenic factor vascular endothelial growth factor-A is perturbed in a range of retinal neovascular diseases. Some of the pathways by which PEDF exerts its actions on cells have now been defined. Peptide fragments of PEDF carry biological activity and may be valuable therapeutic agents that readily penetrate the eye.

UR - http://www.scopus.com/inward/record.url?scp=4043074205&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4043074205&partnerID=8YFLogxK

U2 - 10.1016/j.preteyeres.2004.05.002

DO - 10.1016/j.preteyeres.2004.05.002

M3 - Review article

C2 - 15302351

AN - SCOPUS:4043074205

VL - 23

SP - 561

EP - 577

JO - Progress in Retinal and Eye Research

JF - Progress in Retinal and Eye Research

SN - 1350-9462

IS - 5

ER -