Neuroprotective Properties of Dietary Polyphenols in Parkinson's Disease

Altaf S. Darvesh, Mckenna Mcclure, Prabodh Sadana, Chris Paxos, Werner J. Geldenhuys, Joshua D. Lambert, Tariq M. Haqqi, Jason R. Richardson

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder caused by loss of dopaminergic neurons in the substantia nigra. Although PD is primarily classified as a movement disorder, characterized by abnormal gait, shaking, rigidity, tremors, and slowness of movement, cognitive decline and dementia are also seen in advanced stages. The current pharmacotherapy of PD only manages the symptoms and is ineffective in preventing the continued loss of dopamine neurons. PD medications may also lose their efficacy in advanced stages. Thus, there exists a critical need to explore novel and alternative treatment strategies for PD. Both inflammation and oxidative stress have been strongly implicated in the dopaminergic neurodegeneration seen in PD. Dietary polyphenols, such as anthocyanins in berries, curcumin in turmeric, resveratrol in grapes and peanuts, green-tea catechins, and black-tea theaflavins all possess potent antioxidant and anti-inflammatory properties. This chapter reviews the neuroprotective and therapeutic potential of dietary polyphenols in PD.

Original languageEnglish (US)
Title of host publicationNeuroprotective Effects of Phytochemicals in Neurological Disorders
Publisherwiley
Pages243-263
Number of pages21
ISBN (Electronic)9781119155195
ISBN (Print)9781119155140
DOIs
StatePublished - Jan 2 2017

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All Science Journal Classification (ASJC) codes

  • Medicine(all)
  • Neuroscience(all)

Cite this

Darvesh, A. S., Mcclure, M., Sadana, P., Paxos, C., Geldenhuys, W. J., Lambert, J. D., Haqqi, T. M., & Richardson, J. R. (2017). Neuroprotective Properties of Dietary Polyphenols in Parkinson's Disease. In Neuroprotective Effects of Phytochemicals in Neurological Disorders (pp. 243-263). wiley. https://doi.org/10.1002/9781119155195.ch11