TY - JOUR
T1 - Neuropsychologic functioning in children with autism
T2 - Further evidence for disordered complex information-processing
AU - Williams, Diane L.
AU - Goldstein, Gerald
AU - Minshew, Nancy J.
N1 - Funding Information:
This research was funded by a grant from the National Institute of Child Health and Human Development (NICHD) (U19HD35469) to Nancy J. Minshew, which is part of the NICHD/NIDCD Collaborative Programs for Excellence in Autism (CPEA). Support was also provided by a grant from NIDCD (K23DC006691) to Dr. Williams. The Medical Research Service, Department of Veterans Affairs is also acknowledged for support of this research. We thank our participants and their families for the generous contribution of their time and effort to this project.
Funding Information:
The University of Pittsburgh Medical Center Institutional Review Board approved the study. Procedures were fully explained to all participants and to their parents or guardians. Written informed consent was obtained from their parents or guardians and written assent was obtained from the children. All participants were recruited through the Subject Core of the University of Pittsburgh Collaborative Program of Excellence in Autism funded by the National Institute of Child Health and Human Development.
PY - 2006/10/1
Y1 - 2006/10/1
N2 - A wide range of abilities was assessed in 56 high-functioning children with autism and 56 age- and IQ-matched controls. Stepwise discriminant analyses produced good group discrimination for sensory-perceptual, motor, complex language, and complex memory domains but lower agreement for the reasoning domain than previously obtained for adults. Group discrimination did not occur for attention, simple language, simple memory, and visuospatial domains. Findings provide additional support for a complex information-processing model for autism, previously based on adult data, demonstrating a pattern across domains of selective impairments on measures with high demands for integration of information and sparing when demands were low. Children as compared to adults with autism exhibited more prominent sensory-perceptual symptoms and less pronounced reasoning deficits reflecting brain maturation.
AB - A wide range of abilities was assessed in 56 high-functioning children with autism and 56 age- and IQ-matched controls. Stepwise discriminant analyses produced good group discrimination for sensory-perceptual, motor, complex language, and complex memory domains but lower agreement for the reasoning domain than previously obtained for adults. Group discrimination did not occur for attention, simple language, simple memory, and visuospatial domains. Findings provide additional support for a complex information-processing model for autism, previously based on adult data, demonstrating a pattern across domains of selective impairments on measures with high demands for integration of information and sparing when demands were low. Children as compared to adults with autism exhibited more prominent sensory-perceptual symptoms and less pronounced reasoning deficits reflecting brain maturation.
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U2 - 10.1080/09297040600681190
DO - 10.1080/09297040600681190
M3 - Article
C2 - 16911973
AN - SCOPUS:33747600446
SN - 0929-7049
VL - 12
SP - 279
EP - 298
JO - Child Neuropsychology
JF - Child Neuropsychology
IS - 4-5
ER -