Abstract
The 'paradigm shift' in the title of this article refers to molecular biology. The real challenge to molecular biologists interested in applying their methods to an understanding of psychiatric disorders involves the development of models that account for gene/environment/development interaction. Because of the existence of homologous animal models of additive disorders, as well as a rich body of clinical observations and clinical and behavioral research, and recent data suggesting that chronic exposure to addictive drugs results in changes in gene expression in neurons from behaviorally relevant brain regions, additive disorders offer a serendipitous model (to molecular biologists) that may have relevance to subsequent application in other areas of psychiatry and psychology.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 169-179 |
| Number of pages | 11 |
| Journal | Neuropsychopharmacology |
| Volume | 14 |
| Issue number | 3 |
| DOIs | |
| State | Published - Jan 1 1996 |
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All Science Journal Classification (ASJC) codes
- Pharmacology
- Psychiatry and Mental health
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Neuropsychopharmacology : Are we ready for a paradigm shift? / Meyer, Roger.
In: Neuropsychopharmacology, Vol. 14, No. 3, 01.01.1996, p. 169-179.Research output: Contribution to journal › Article
TY - JOUR
T1 - Neuropsychopharmacology
T2 - Are we ready for a paradigm shift?
AU - Meyer, Roger
PY - 1996/1/1
Y1 - 1996/1/1
N2 - The 'paradigm shift' in the title of this article refers to molecular biology. The real challenge to molecular biologists interested in applying their methods to an understanding of psychiatric disorders involves the development of models that account for gene/environment/development interaction. Because of the existence of homologous animal models of additive disorders, as well as a rich body of clinical observations and clinical and behavioral research, and recent data suggesting that chronic exposure to addictive drugs results in changes in gene expression in neurons from behaviorally relevant brain regions, additive disorders offer a serendipitous model (to molecular biologists) that may have relevance to subsequent application in other areas of psychiatry and psychology.
AB - The 'paradigm shift' in the title of this article refers to molecular biology. The real challenge to molecular biologists interested in applying their methods to an understanding of psychiatric disorders involves the development of models that account for gene/environment/development interaction. Because of the existence of homologous animal models of additive disorders, as well as a rich body of clinical observations and clinical and behavioral research, and recent data suggesting that chronic exposure to addictive drugs results in changes in gene expression in neurons from behaviorally relevant brain regions, additive disorders offer a serendipitous model (to molecular biologists) that may have relevance to subsequent application in other areas of psychiatry and psychology.
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UR - http://www.scopus.com/inward/citedby.url?scp=0030000511&partnerID=8YFLogxK
U2 - 10.1016/0893-133X(95)00074-N
DO - 10.1016/0893-133X(95)00074-N
M3 - Article
VL - 14
SP - 169
EP - 179
JO - Neuropsychopharmacology
JF - Neuropsychopharmacology
SN - 0893-133X
IS - 3
ER -