Neurotoxicants and central catecholamine systems

Richard Mailman, M. H. Lewis

Research output: Contribution to journalReview article

10 Citations (Scopus)

Abstract

The ubiquitous functional roles of brain catecholamines have led to the notion that in vitro neurochemical changes in these systems may predict neurotoxicity. Conversely, others have argued that the appropriate use of neurochemical methods is for testing specific hypotheses that are developed based on observed phenomena. Three studies from this laboratory are presented in support of the latter hypothesis. The first example is with inorganic lead, a major environmental pollutant. The effects of small doses of lead on CNS development have been difficult to quantify or study mechanistically. However, the serendipitous finding that lead exposure during early postnatal development increased lithium-induced polydipsia (LIP) has provided clues that have permitted testing of specific neurochemical hypotheses related to dopamine systems. Conversely, the administration of either trimethyl- or triethyltin to rats during perinatal periods causes profound neurotoxicity. However, although some changes in the neurochemistry of catecholamine systems have been found, these data have provided little insight into either the cause or sequelae of toxicity. Finally, the food color erythrosin (FD & C Red #3) was hypothesized to be a neurotoxicant because it disrupted neurotransmitter uptake in vitro. Our data suggested that this was an artifact of the methodology, a position supported by clinical and behavioral studies. These data provide examples of the strengths and weaknesses in neurochemical approaches to neurotoxicity.

Original languageEnglish (US)
Pages (from-to)123-140
Number of pages18
JournalNeuroToxicology
Volume8
Issue number1
StatePublished - 1987

Fingerprint

Catecholamines
Erythrosine
Polydipsia
Neurochemistry
Environmental Pollutants
Testing
Lithium
Artifacts
Neurotransmitter Agents
Toxicity
Rats
Dopamine
Brain
Color
Food
In Vitro Techniques
Lead
Clinical Studies
triethyltin

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Cellular and Molecular Neuroscience
  • Toxicology

Cite this

Mailman, Richard ; Lewis, M. H. / Neurotoxicants and central catecholamine systems. In: NeuroToxicology. 1987 ; Vol. 8, No. 1. pp. 123-140.
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Mailman, R & Lewis, MH 1987, 'Neurotoxicants and central catecholamine systems', NeuroToxicology, vol. 8, no. 1, pp. 123-140.

Neurotoxicants and central catecholamine systems. / Mailman, Richard; Lewis, M. H.

In: NeuroToxicology, Vol. 8, No. 1, 1987, p. 123-140.

Research output: Contribution to journalReview article

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