Neurovascular coupling and decoupling in the cortex during voluntary locomotion

Bing Xing Huo, Jared B. Smith, Patrick J. Drew

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Hemodynamic signals are widely used to infer neural activity in the brain. We tested the hypothesis that hemodynamic signals faithfully report neural activity during voluntary behaviors by measuring cerebral blood volume (CBV) and neural activity in the somatosensory cortex and frontal cortex of head-fixed mice during locomotion. Locomotion induced a large and robust increase in firing rate and gamma-band (40-100 Hz) power in the local field potential in the limb representations in somatosensory cortex, and was accompanied by increases in CBV, demonstrating that hemodynamic signals are coupled with neural activity in this region. However, in the frontal cortex, CBV did not change during locomotion, but firing rate and gamma-band power both increased, indicating a decoupling of neural activity from the hemodynamic signal. These results show that hemodynamic signals are not faithful indicators of the mean neural activity in the frontal cortex during locomotion; thus, the results from fMRI and other hemodynamic imaging methodologies for studying neural processes must be interpreted with caution.

Original languageEnglish (US)
Pages (from-to)10975-10981
Number of pages7
JournalJournal of Neuroscience
Volume34
Issue number33
DOIs
StatePublished - Jan 1 2014

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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