New biomimetic aggrecan for treatment of intervertebral disc degeneration

D. Madende; K. Prudnikova; S. Lightfoot; Edward Vresilovic; M. Marcolongo

doi:10.1109/NEBC.2012.6207039

New biomimetic aggrecan for treatment of intervertebral disc degeneration

D. Madende, K. Prudnikova, S. Lightfoot, Edward Vresilovic, M. Marcolongo

Department of Orthopaedics and Rehabilitation

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

Lower back pain resulting from intervertebral disc degeneration is one of the leading musculoskeletal disorders confronting our health system. Disc degeneration is accompanied by a decrease in aggrecan content in the nucleus pulposus. A possible approach to mechanically stabilizing the disc early in the degenerative cascade is by increasing the concentration of aggrecan in the nucleus to normal level thereby increasing hydration and intradiscal pressure. Treatment with natural aggrecan, however, is cost prohibitive. Here we report synthesis and characterization of an enzymatically-resistant, biomimetic aggrecan consisting of a synthetic polymer core with covalently attached chondroitin sulfate bristles. Our novel biomimetic aggrecan mimics the structure and osmotic properties of natural aggrecan and is cytocompatible.

Original language	English (US)
Title of host publication	2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012
Pages	213-214
Number of pages	2
DOIs	https://doi.org/10.1109/NEBC.2012.6207039
State	Published - Jun 29 2012
Event	38th Annual Northeast Bioengineering Conference, NEBEC 2012 - Philadelphia, PA, United States Duration: Mar 16 2012 → Mar 18 2012

Publication series

Name	2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012

Other

Other	38th Annual Northeast Bioengineering Conference, NEBEC 2012
Country	United States
City	Philadelphia, PA
Period	3/16/12 → 3/18/12

All Science Journal Classification (ASJC) codes

Bioengineering

Access to Document

10.1109/NEBC.2012.6207039

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title = "New biomimetic aggrecan for treatment of intervertebral disc degeneration",

abstract = "Lower back pain resulting from intervertebral disc degeneration is one of the leading musculoskeletal disorders confronting our health system. Disc degeneration is accompanied by a decrease in aggrecan content in the nucleus pulposus. A possible approach to mechanically stabilizing the disc early in the degenerative cascade is by increasing the concentration of aggrecan in the nucleus to normal level thereby increasing hydration and intradiscal pressure. Treatment with natural aggrecan, however, is cost prohibitive. Here we report synthesis and characterization of an enzymatically-resistant, biomimetic aggrecan consisting of a synthetic polymer core with covalently attached chondroitin sulfate bristles. Our novel biomimetic aggrecan mimics the structure and osmotic properties of natural aggrecan and is cytocompatible.",

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Madende, D, Prudnikova, K, Lightfoot, S, Vresilovic, E & Marcolongo, M 2012, New biomimetic aggrecan for treatment of intervertebral disc degeneration. in 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012., 6207039, 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012, pp. 213-214, 38th Annual Northeast Bioengineering Conference, NEBEC 2012, Philadelphia, PA, United States, 3/16/12. https://doi.org/10.1109/NEBC.2012.6207039

New biomimetic aggrecan for treatment of intervertebral disc degeneration. / Madende, D.; Prudnikova, K.; Lightfoot, S.; Vresilovic, Edward; Marcolongo, M.

2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012. 2012. p. 213-214 6207039 (2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

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