TY - GEN
T1 - New biomimetic aggrecan for treatment of intervertebral disc degeneration
AU - Madende, D.
AU - Prudnikova, K.
AU - Lightfoot, S.
AU - Vresilovic, Edward
AU - Marcolongo, M.
PY - 2012/6/29
Y1 - 2012/6/29
N2 - Lower back pain resulting from intervertebral disc degeneration is one of the leading musculoskeletal disorders confronting our health system. Disc degeneration is accompanied by a decrease in aggrecan content in the nucleus pulposus. A possible approach to mechanically stabilizing the disc early in the degenerative cascade is by increasing the concentration of aggrecan in the nucleus to normal level thereby increasing hydration and intradiscal pressure. Treatment with natural aggrecan, however, is cost prohibitive. Here we report synthesis and characterization of an enzymatically-resistant, biomimetic aggrecan consisting of a synthetic polymer core with covalently attached chondroitin sulfate bristles. Our novel biomimetic aggrecan mimics the structure and osmotic properties of natural aggrecan and is cytocompatible.
AB - Lower back pain resulting from intervertebral disc degeneration is one of the leading musculoskeletal disorders confronting our health system. Disc degeneration is accompanied by a decrease in aggrecan content in the nucleus pulposus. A possible approach to mechanically stabilizing the disc early in the degenerative cascade is by increasing the concentration of aggrecan in the nucleus to normal level thereby increasing hydration and intradiscal pressure. Treatment with natural aggrecan, however, is cost prohibitive. Here we report synthesis and characterization of an enzymatically-resistant, biomimetic aggrecan consisting of a synthetic polymer core with covalently attached chondroitin sulfate bristles. Our novel biomimetic aggrecan mimics the structure and osmotic properties of natural aggrecan and is cytocompatible.
UR - http://www.scopus.com/inward/record.url?scp=84862734180&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862734180&partnerID=8YFLogxK
U2 - 10.1109/NEBC.2012.6207039
DO - 10.1109/NEBC.2012.6207039
M3 - Conference contribution
AN - SCOPUS:84862734180
SN - 9781467311410
T3 - 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012
SP - 213
EP - 214
BT - 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012
T2 - 38th Annual Northeast Bioengineering Conference, NEBEC 2012
Y2 - 16 March 2012 through 18 March 2012
ER -