New biomimetic aggrecan for treatment of intervertebral disc degeneration

D. Madende, K. Prudnikova, S. Lightfoot, Edward Vresilovic, M. Marcolongo

Research output: Chapter in Book/Report/Conference proceedingConference contribution

1 Scopus citations

Abstract

Lower back pain resulting from intervertebral disc degeneration is one of the leading musculoskeletal disorders confronting our health system. Disc degeneration is accompanied by a decrease in aggrecan content in the nucleus pulposus. A possible approach to mechanically stabilizing the disc early in the degenerative cascade is by increasing the concentration of aggrecan in the nucleus to normal level thereby increasing hydration and intradiscal pressure. Treatment with natural aggrecan, however, is cost prohibitive. Here we report synthesis and characterization of an enzymatically-resistant, biomimetic aggrecan consisting of a synthetic polymer core with covalently attached chondroitin sulfate bristles. Our novel biomimetic aggrecan mimics the structure and osmotic properties of natural aggrecan and is cytocompatible.

Original languageEnglish (US)
Title of host publication2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012
Pages213-214
Number of pages2
DOIs
Publication statusPublished - Jun 29 2012
Event38th Annual Northeast Bioengineering Conference, NEBEC 2012 - Philadelphia, PA, United States
Duration: Mar 16 2012Mar 18 2012

Publication series

Name2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012

Other

Other38th Annual Northeast Bioengineering Conference, NEBEC 2012
CountryUnited States
CityPhiladelphia, PA
Period3/16/123/18/12

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All Science Journal Classification (ASJC) codes

  • Bioengineering

Cite this

Madende, D., Prudnikova, K., Lightfoot, S., Vresilovic, E., & Marcolongo, M. (2012). New biomimetic aggrecan for treatment of intervertebral disc degeneration. In 2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012 (pp. 213-214). [6207039] (2012 38th Annual Northeast Bioengineering Conference, NEBEC 2012). https://doi.org/10.1109/NEBC.2012.6207039