New cancers after autotransplantations for multiple myeloma

Anuj Mahindra, Girindra Raval, Paulette Mehta, Ruta Brazauskas, Mei Jie Zhang, Xiaobo Zhong, Jennifer M. Bird, César O. Freytes, Gregory A. Hale, Roger Herzig, Leona A. Holmberg, Rammurti T. Kamble, Shaji Kumar, Hillard M. Lazarus, Navneet S. Majhail, David I. Marks, Jan S. Moreb, Richard Olsson, Wael Saber, Bipin N. Savani & 12 others Gary J. Schiller, Jason Tay, Dan T. Vogl, Edmund K. Waller, Peter H. Wiernik, Baldeep Wirk, Sagar Lonial, Amrita Y. Krishnan, Angela Dispenzieri, Nancy A. Brandenburg, Robert Peter Gale, Parameswaran N. Hari

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

We describe baseline incidence and risk factors for new cancers in 4161 persons receiving autotransplants for multiple myeloma in the United States from 1990 to 2010. Observed incidence of invasive new cancers was compared with expected incidence relative to the US population. The cohort represented 13,387 person-years at-risk. In total, 163 new cancers were observed, for a crude incidence rate of 1.2 new cancers per 100 person-years and cumulative incidences of 2.6% (95% confidence interval [CI], 2.09 to 3.17), 4.2% (95% CI, 3.49 to 5.00), and 6.1% (95% CI, 5.08 to 7.24) at 3, 5, and 7years, respectively. The incidence of new cancers in the autotransplantation cohort was similar to age-, race-, and gender-adjusted comparison subjects with an observed/expected (O/E) ratio of 1.00 (99% CI, .81 to 1.22). However, acute myeloid leukemia and melanoma were observed at higher than expected rates with O/E ratios of 5.19 (99% CI, 1.67 to 12.04; P=0004), and 3.58 (99% CI, 1.82 to 6.29; P < .0001), respectively. Obesity, older age, and male gender were associated with increased risks of new cancers in multivariate analyses. This large data set provides a baseline for comparison and defines the histologic type specific risk for new cancers in patients with MM receiving postautotransplantation therapies, such as maintenance.

Original languageEnglish (US)
Pages (from-to)738-745
Number of pages8
JournalBiology of Blood and Marrow Transplantation
Volume21
Issue number4
DOIs
StatePublished - Apr 1 2015

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Autologous Transplantation
Multiple Myeloma
Confidence Intervals
Incidence
Neoplasms
Autografts
Acute Myeloid Leukemia
Melanoma
Multivariate Analysis
Obesity
Maintenance
Population

All Science Journal Classification (ASJC) codes

  • Hematology
  • Transplantation

Cite this

Mahindra, A., Raval, G., Mehta, P., Brazauskas, R., Zhang, M. J., Zhong, X., ... Hari, P. N. (2015). New cancers after autotransplantations for multiple myeloma. Biology of Blood and Marrow Transplantation, 21(4), 738-745. https://doi.org/10.1016/j.bbmt.2014.12.028
Mahindra, Anuj ; Raval, Girindra ; Mehta, Paulette ; Brazauskas, Ruta ; Zhang, Mei Jie ; Zhong, Xiaobo ; Bird, Jennifer M. ; Freytes, César O. ; Hale, Gregory A. ; Herzig, Roger ; Holmberg, Leona A. ; Kamble, Rammurti T. ; Kumar, Shaji ; Lazarus, Hillard M. ; Majhail, Navneet S. ; Marks, David I. ; Moreb, Jan S. ; Olsson, Richard ; Saber, Wael ; Savani, Bipin N. ; Schiller, Gary J. ; Tay, Jason ; Vogl, Dan T. ; Waller, Edmund K. ; Wiernik, Peter H. ; Wirk, Baldeep ; Lonial, Sagar ; Krishnan, Amrita Y. ; Dispenzieri, Angela ; Brandenburg, Nancy A. ; Gale, Robert Peter ; Hari, Parameswaran N. / New cancers after autotransplantations for multiple myeloma. In: Biology of Blood and Marrow Transplantation. 2015 ; Vol. 21, No. 4. pp. 738-745.
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abstract = "We describe baseline incidence and risk factors for new cancers in 4161 persons receiving autotransplants for multiple myeloma in the United States from 1990 to 2010. Observed incidence of invasive new cancers was compared with expected incidence relative to the US population. The cohort represented 13,387 person-years at-risk. In total, 163 new cancers were observed, for a crude incidence rate of 1.2 new cancers per 100 person-years and cumulative incidences of 2.6{\%} (95{\%} confidence interval [CI], 2.09 to 3.17), 4.2{\%} (95{\%} CI, 3.49 to 5.00), and 6.1{\%} (95{\%} CI, 5.08 to 7.24) at 3, 5, and 7years, respectively. The incidence of new cancers in the autotransplantation cohort was similar to age-, race-, and gender-adjusted comparison subjects with an observed/expected (O/E) ratio of 1.00 (99{\%} CI, .81 to 1.22). However, acute myeloid leukemia and melanoma were observed at higher than expected rates with O/E ratios of 5.19 (99{\%} CI, 1.67 to 12.04; P=0004), and 3.58 (99{\%} CI, 1.82 to 6.29; P < .0001), respectively. Obesity, older age, and male gender were associated with increased risks of new cancers in multivariate analyses. This large data set provides a baseline for comparison and defines the histologic type specific risk for new cancers in patients with MM receiving postautotransplantation therapies, such as maintenance.",
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Mahindra, A, Raval, G, Mehta, P, Brazauskas, R, Zhang, MJ, Zhong, X, Bird, JM, Freytes, CO, Hale, GA, Herzig, R, Holmberg, LA, Kamble, RT, Kumar, S, Lazarus, HM, Majhail, NS, Marks, DI, Moreb, JS, Olsson, R, Saber, W, Savani, BN, Schiller, GJ, Tay, J, Vogl, DT, Waller, EK, Wiernik, PH, Wirk, B, Lonial, S, Krishnan, AY, Dispenzieri, A, Brandenburg, NA, Gale, RP & Hari, PN 2015, 'New cancers after autotransplantations for multiple myeloma', Biology of Blood and Marrow Transplantation, vol. 21, no. 4, pp. 738-745. https://doi.org/10.1016/j.bbmt.2014.12.028

New cancers after autotransplantations for multiple myeloma. / Mahindra, Anuj; Raval, Girindra; Mehta, Paulette; Brazauskas, Ruta; Zhang, Mei Jie; Zhong, Xiaobo; Bird, Jennifer M.; Freytes, César O.; Hale, Gregory A.; Herzig, Roger; Holmberg, Leona A.; Kamble, Rammurti T.; Kumar, Shaji; Lazarus, Hillard M.; Majhail, Navneet S.; Marks, David I.; Moreb, Jan S.; Olsson, Richard; Saber, Wael; Savani, Bipin N.; Schiller, Gary J.; Tay, Jason; Vogl, Dan T.; Waller, Edmund K.; Wiernik, Peter H.; Wirk, Baldeep; Lonial, Sagar; Krishnan, Amrita Y.; Dispenzieri, Angela; Brandenburg, Nancy A.; Gale, Robert Peter; Hari, Parameswaran N.

In: Biology of Blood and Marrow Transplantation, Vol. 21, No. 4, 01.04.2015, p. 738-745.

Research output: Contribution to journalArticle

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T1 - New cancers after autotransplantations for multiple myeloma

AU - Mahindra, Anuj

AU - Raval, Girindra

AU - Mehta, Paulette

AU - Brazauskas, Ruta

AU - Zhang, Mei Jie

AU - Zhong, Xiaobo

AU - Bird, Jennifer M.

AU - Freytes, César O.

AU - Hale, Gregory A.

AU - Herzig, Roger

AU - Holmberg, Leona A.

AU - Kamble, Rammurti T.

AU - Kumar, Shaji

AU - Lazarus, Hillard M.

AU - Majhail, Navneet S.

AU - Marks, David I.

AU - Moreb, Jan S.

AU - Olsson, Richard

AU - Saber, Wael

AU - Savani, Bipin N.

AU - Schiller, Gary J.

AU - Tay, Jason

AU - Vogl, Dan T.

AU - Waller, Edmund K.

AU - Wiernik, Peter H.

AU - Wirk, Baldeep

AU - Lonial, Sagar

AU - Krishnan, Amrita Y.

AU - Dispenzieri, Angela

AU - Brandenburg, Nancy A.

AU - Gale, Robert Peter

AU - Hari, Parameswaran N.

PY - 2015/4/1

Y1 - 2015/4/1

N2 - We describe baseline incidence and risk factors for new cancers in 4161 persons receiving autotransplants for multiple myeloma in the United States from 1990 to 2010. Observed incidence of invasive new cancers was compared with expected incidence relative to the US population. The cohort represented 13,387 person-years at-risk. In total, 163 new cancers were observed, for a crude incidence rate of 1.2 new cancers per 100 person-years and cumulative incidences of 2.6% (95% confidence interval [CI], 2.09 to 3.17), 4.2% (95% CI, 3.49 to 5.00), and 6.1% (95% CI, 5.08 to 7.24) at 3, 5, and 7years, respectively. The incidence of new cancers in the autotransplantation cohort was similar to age-, race-, and gender-adjusted comparison subjects with an observed/expected (O/E) ratio of 1.00 (99% CI, .81 to 1.22). However, acute myeloid leukemia and melanoma were observed at higher than expected rates with O/E ratios of 5.19 (99% CI, 1.67 to 12.04; P=0004), and 3.58 (99% CI, 1.82 to 6.29; P < .0001), respectively. Obesity, older age, and male gender were associated with increased risks of new cancers in multivariate analyses. This large data set provides a baseline for comparison and defines the histologic type specific risk for new cancers in patients with MM receiving postautotransplantation therapies, such as maintenance.

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Mahindra A, Raval G, Mehta P, Brazauskas R, Zhang MJ, Zhong X et al. New cancers after autotransplantations for multiple myeloma. Biology of Blood and Marrow Transplantation. 2015 Apr 1;21(4):738-745. https://doi.org/10.1016/j.bbmt.2014.12.028