New devices for pediatric mechanical circulatory support

Linda B. Pauliks, Akif Ündar

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

PURPOSE OF REVIEW: In adult patients with advanced heart failure, mechanical circulatory support devices (MCSDs) offer a valid treatment option. MCSDs can serve as a bridge to transplant, bridge to recovery or destination therapy. In the REMATCH trial, MCSDs outperformed medical management for long-term support of end-stage heart failure. Until recently, pediatric patients could not fully benefit from this development due to lack of suitable devices. This review provides an overview of pediatric MCSDs currently available in the US and those in the development stage. We discuss the emerging role of extracorporeal membrane oxygenation compared with MCSDs. RECENT FINDINGS: Small patients with a body-surface area below 0.7 m now have access to the pediatric Berlin Heart Excor. For larger children, several adult MCSDs may be suitable, including the Abiomed BVS-5000, Thoratec, HeartMate and DeBakey MCSD. Five pediatric MCSDs supported by NIH contracts issued in 2004 are now in preclinical testing. Other pediatric MCSDs are already in clinical use abroad on a small scale. SUMMARY: There is mounting experience with MCSDs in children with advanced heart failure. MCSDs will increasingly have to be considered as a treatment option for pediatric heart-transplant candidates and may serve as a bridge to recovery.

Original languageEnglish (US)
Pages (from-to)91-96
Number of pages6
JournalCurrent Opinion in Cardiology
Volume23
Issue number2
DOIs
StatePublished - Mar 1 2008

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Pediatrics
Equipment and Supplies
Heart Failure
Transplants
Extracorporeal Membrane Oxygenation
Body Surface Area
Berlin
Contracts
Therapeutics

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

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New devices for pediatric mechanical circulatory support. / Pauliks, Linda B.; Ündar, Akif.

In: Current Opinion in Cardiology, Vol. 23, No. 2, 01.03.2008, p. 91-96.

Research output: Contribution to journalReview article

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