New insights into the role of nuclear factor-κB, a ubiquitous transcription factor in the initiation of diseases

Fei Chen, Vince Castranova, Xianglin Shi, Laurence Demers

Research output: Contribution to journalReview article

627 Scopus citations

Abstract

Nuclear factor-κB (NF-κB) is a ubiquitous transcription factor that governs the expression of genes encoding cytokines, chemokines, growth factors, cell adhesion molecules, and some acute phase proteins in health and in various disease states. NF-κB is activated by several agents, including cytokines, oxidant free radicals, inhaled particles, ultraviolet irradiation, and bacterial or vital products. Inappropriate activation of NF-κB has been linked to inflammatory events associated with autoimmune arthritis, asthma, septic shock, lung fibrosis, glomerulonephritis, atherosclerosis, and AIDS. In contrast, complete and persistent inhibition of NF-κB has been linked directly to apoptosis, inappropriate immune cell development, and delayed cell growth. Therefore, development of modulatory strategies targeting this transcription factor may provide a novel therapeutic tool for the treatment or prevention of various diseases.

Original languageEnglish (US)
Pages (from-to)7-17
Number of pages11
JournalClinical Chemistry
Volume45
Issue number1
StatePublished - Jan 23 1999

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Biochemistry, medical

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