TY - GEN
T1 - New iron-oxide particles for magnetic nanoparticle hyperthermia
T2 - 2013 SPIE Conference: Energy-Based Treatment of Tissue and Assessment VII
AU - Hedayati, Mohammad
AU - Attaluri, Anilchandra
AU - Bordelon, David
AU - Goh, R.
AU - Armour, Michael
AU - Zhou, Haoming
AU - Cornejo, Christine
AU - Wabler, Michele
AU - Zhang, Yonggang
AU - DeWeese, Theodore
AU - Ivkov, Robert
PY - 2013
Y1 - 2013
N2 - Magnetic nanoparticle hyperthermia (mNHP) is regarded as a promising minimally invasive procedure. These nanoparticles generate heat when exposed to alternating magnetic fields (AMFs) and thus have shown a potential for selective delivery of heat to a target such as a cancer cell. Despite the great promise however, successful clinical translation has been limited in part by technical challenges of selectively delivering heat only to the target tissue. Interaction of AMF with tissues also deposits heat through Joule heating via eddy currents. Considerations of patient safety thus constrain the choice of AMF power and frequency to values that are insufficient to produce desirable heating from available nanoparticle formulations. Therefore, considerable effort must be directed to the design of particles and the AMF device to maximize the specific delivery of heat to the intended target while minimizing the unintended and non-specific heating. We have recently developed new iron-oxide nanoparticles (IONPs) having much higher heating capability at the clinically relevant amplitudes and frequencies than other formulations. Here, we utilize a new rectangular coil designed for treating multi well tissue culture plate and show that these particles are superior to two commercially available IONPs for hyperthermia of DU145 prostate cancer cells in culture. We report results of pilot in-vivo experiments using the DU145 human prostate xenograft model in nude male mouse. AMF treatment yielded an intratumor temperature rise > 10°C in <10 min heating (AMF amplitude 29 kA/m @160 kHz) with ∼4 mg nanoparticle /g tumor while maintaining rectal (core) temperature well within physiological range.
AB - Magnetic nanoparticle hyperthermia (mNHP) is regarded as a promising minimally invasive procedure. These nanoparticles generate heat when exposed to alternating magnetic fields (AMFs) and thus have shown a potential for selective delivery of heat to a target such as a cancer cell. Despite the great promise however, successful clinical translation has been limited in part by technical challenges of selectively delivering heat only to the target tissue. Interaction of AMF with tissues also deposits heat through Joule heating via eddy currents. Considerations of patient safety thus constrain the choice of AMF power and frequency to values that are insufficient to produce desirable heating from available nanoparticle formulations. Therefore, considerable effort must be directed to the design of particles and the AMF device to maximize the specific delivery of heat to the intended target while minimizing the unintended and non-specific heating. We have recently developed new iron-oxide nanoparticles (IONPs) having much higher heating capability at the clinically relevant amplitudes and frequencies than other formulations. Here, we utilize a new rectangular coil designed for treating multi well tissue culture plate and show that these particles are superior to two commercially available IONPs for hyperthermia of DU145 prostate cancer cells in culture. We report results of pilot in-vivo experiments using the DU145 human prostate xenograft model in nude male mouse. AMF treatment yielded an intratumor temperature rise > 10°C in <10 min heating (AMF amplitude 29 kA/m @160 kHz) with ∼4 mg nanoparticle /g tumor while maintaining rectal (core) temperature well within physiological range.
UR - http://www.scopus.com/inward/record.url?scp=84878614791&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84878614791&partnerID=8YFLogxK
U2 - 10.1117/12.2019834
DO - 10.1117/12.2019834
M3 - Conference contribution
AN - SCOPUS:84878614791
SN - 9780819493538
T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE
BT - Energy-Based Treatment of Tissue and Assessment VII
Y2 - 3 February 2013 through 4 February 2013
ER -