New jaspamide derivatives with antimicrofilament activity from the sponge Jaspis splendans

Fulvio Gala, Maria Valeria D'Auria, Simona De Marino, Franco Zollo, Charles Smith, Jean E. Copper, Angela Zampella

Research output: Contribution to journalArticlepeer-review

24 Scopus citations

Abstract

A reinvestigation of Jaspis splendans afforded the novel compounds jaspamide D-G plus the known compounds jaspamide and jaspamides B and C. All compounds exhibited potent cytotoxic activities and were shown to cause microfilament disruption. Biological activity and structural elucidation are reported here.

Original languageEnglish (US)
Pages (from-to)5212-5219
Number of pages8
JournalTetrahedron
Volume63
Issue number24
DOIs
StatePublished - Jun 11 2007

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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