The mutagenic effect of a number of procarcinogenic compounds has been compared in two groups of Drosophila melanogaster strains differing in the insecticide resistance-associated cytochrome P-450. Heterozygotes y++/+wsn3 of insecticide-sensitive strains were shown to be sensitive to the mutagenic effects of aflatoxin B1, 1,2-dibromo-3-chloropropane and nitrozamines, but failed to detect mutagenicity of the benzo(a)pyrene and acethylaminofluorenes. In contrast, the newly established DDT-resistant strains were found to be sensitive to the mutagenecity of BP and 2- AAF in the SMART assay. Mechanisms of the sensitivity of the newly constructed strains to BP and 2-AAF are discussed.
|Original language||English (US)|
|Number of pages||6|
|State||Published - Sep 1 1997|
All Science Journal Classification (ASJC) codes
- Cancer Research