Newly constructed insecticide-resistant D. melanogaster strains with elevated sensitivity to the mutagenic effect of benzo(a)pyrene and 2-acethylaminofluorene

M. A. Dobrovolskaya, V. S. Spiegelman, G. A. Belitsky

Research output: Contribution to journalArticle

Abstract

The mutagenic effect of a number of procarcinogenic compounds has been compared in two groups of Drosophila melanogaster strains differing in the insecticide resistance-associated cytochrome P-450. Heterozygotes y++/+wsn3 of insecticide-sensitive strains were shown to be sensitive to the mutagenic effects of aflatoxin B1, 1,2-dibromo-3-chloropropane and nitrozamines, but failed to detect mutagenicity of the benzo(a)pyrene and acethylaminofluorenes. In contrast, the newly established DDT-resistant strains were found to be sensitive to the mutagenecity of BP and 2- AAF in the SMART assay. Mechanisms of the sensitivity of the newly constructed strains to BP and 2-AAF are discussed.

Original languageEnglish (US)
Pages (from-to)185-190
Number of pages6
JournalExperimental Oncology
Volume19
Issue number3
StatePublished - Sep 1 1997

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2-Acetylaminofluorene
Benzo(a)pyrene
Insecticides
Insecticide Resistance
Aflatoxin B1
DDT
Heterozygote
Drosophila melanogaster
Cytochrome P-450 Enzyme System
1,2-dibromo-3-chloropropane

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

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abstract = "The mutagenic effect of a number of procarcinogenic compounds has been compared in two groups of Drosophila melanogaster strains differing in the insecticide resistance-associated cytochrome P-450. Heterozygotes y++/+wsn3 of insecticide-sensitive strains were shown to be sensitive to the mutagenic effects of aflatoxin B1, 1,2-dibromo-3-chloropropane and nitrozamines, but failed to detect mutagenicity of the benzo(a)pyrene and acethylaminofluorenes. In contrast, the newly established DDT-resistant strains were found to be sensitive to the mutagenecity of BP and 2- AAF in the SMART assay. Mechanisms of the sensitivity of the newly constructed strains to BP and 2-AAF are discussed.",
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Newly constructed insecticide-resistant D. melanogaster strains with elevated sensitivity to the mutagenic effect of benzo(a)pyrene and 2-acethylaminofluorene. / Dobrovolskaya, M. A.; Spiegelman, V. S.; Belitsky, G. A.

In: Experimental Oncology, Vol. 19, No. 3, 01.09.1997, p. 185-190.

Research output: Contribution to journalArticle

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