Newly constructed insecticide-resistant D. melanogaster strains with elevated sensitivity to the mutagenic effect of benzo(a)pyrene and 2-acethylaminofluorene

M. A. Dobrovolskaya, V. S. Spiegelman, G. A. Belitsky

Research output: Contribution to journalArticle

Abstract

The mutagenic effect of a number of procarcinogenic compounds has been compared in two groups of Drosophila melanogaster strains differing in the insecticide resistance-associated cytochrome P-450. Heterozygotes y++/+wsn3 of insecticide-sensitive strains were shown to be sensitive to the mutagenic effects of aflatoxin B1, 1,2-dibromo-3-chloropropane and nitrozamines, but failed to detect mutagenicity of the benzo(a)pyrene and acethylaminofluorenes. In contrast, the newly established DDT-resistant strains were found to be sensitive to the mutagenecity of BP and 2- AAF in the SMART assay. Mechanisms of the sensitivity of the newly constructed strains to BP and 2-AAF are discussed.

Original languageEnglish (US)
Pages (from-to)185-190
Number of pages6
JournalExperimental Oncology
Volume19
Issue number3
StatePublished - Sep 1 1997

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Newly constructed insecticide-resistant D. melanogaster strains with elevated sensitivity to the mutagenic effect of benzo(a)pyrene and 2-acethylaminofluorene'. Together they form a unique fingerprint.

  • Cite this