NF-κB and tPA Signaling in Kidney and Other Diseases

Samantha White, Ling Lin, Kebin Hu

Research output: Contribution to journalReview article

Abstract

The activation of the nuclear factor-κB (NF-κB) pathway plays a central role in the initiation and progression of inflammation, which contributes to the pathogenesis and progression of various human diseases including kidney, brain, and other diseases. Tissue plasminogen activator (tPA), a serine protease regulating homeostasis of blood coagulation, fibrinolysis, and matrix degradation, has been shown to act as a cytokine to trigger profound receptor-mediated intracellular events, modulate the NF-κB pathway, and mediate organ dysfunction and injury. In this review, we focus on the current understanding of NF-κB and tPA signaling in the development and progression of kidney disease. Their roles in the nervous and cardiovascular system are also briefly discussed.

Original languageEnglish (US)
JournalCells
Volume9
Issue number6
DOIs
StatePublished - May 29 2020

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