NF-κB p50 subunit knockout impairs late LTP and alters long term memory in the mouse hippocampus

Kensuke Oikawa, Gary L. Odero, Eric Platt, Melanie Neuendorff, Avril Hatherell, Michael Jason Bernstein, Benedict C. Albensi

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Background: Nuclear factor kappa B (NF-κB) is a transcription factor typically expressed with two specific subunits (p50, p65). Investigators have reported that NF-κB is activated during the induction of in vitro long term potentiation (LTP), a paradigm of synaptic plasticity and correlate of memory, suggesting that NF-κB may be necessary for some aspects of memory encoding. Furthermore, NF-κB has been implicated as a potential requirement in behavioral tests of memory. Unfortunately, very little work has been done to explore the effects of deleting specific NF-κB subunits on memory. Studies have shown that NF-κB p50 subunit deletion (p50 -/-) leads to memory deficits, however some recent studies suggest the contrary where p50 -/- mice show enhanced memory in the Morris water maze (MWM). To more critically explore the role of the NF-κB p50 subunit in synaptic plasticity and memory, we assessed long term spatial memory in vivo using the MWM, and synaptic plasticity in vitro utilizing high frequency stimuli capable of eliciting LTP in slices from the hippocampus of NF-κB p50 -/- versus their controls (p50 +/+).Results: We found that the lack of the NF-κB p50 subunit led to significant decreases in late LTP and in selective but significant alterations in MWM tests (i.e., some improvements during acquisition, but deficits during retention).Conclusions: These results support the hypothesis that the NF-κ p50 subunit is required in long term spatial memory in the hippocampus.

Original languageEnglish (US)
Article number45
JournalBMC Neuroscience
Volume13
Issue number1
DOIs
StatePublished - May 3 2012

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Long-Term Memory
NF-kappa B
Long-Term Potentiation
Hippocampus
Neuronal Plasticity
Water
Memory Disorders
Transcription Factors
Research Personnel

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Cellular and Molecular Neuroscience

Cite this

Oikawa, Kensuke ; Odero, Gary L. ; Platt, Eric ; Neuendorff, Melanie ; Hatherell, Avril ; Bernstein, Michael Jason ; Albensi, Benedict C. / NF-κB p50 subunit knockout impairs late LTP and alters long term memory in the mouse hippocampus. In: BMC Neuroscience. 2012 ; Vol. 13, No. 1.
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NF-κB p50 subunit knockout impairs late LTP and alters long term memory in the mouse hippocampus. / Oikawa, Kensuke; Odero, Gary L.; Platt, Eric; Neuendorff, Melanie; Hatherell, Avril; Bernstein, Michael Jason; Albensi, Benedict C.

In: BMC Neuroscience, Vol. 13, No. 1, 45, 03.05.2012.

Research output: Contribution to journalArticle

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AU - Oikawa, Kensuke

AU - Odero, Gary L.

AU - Platt, Eric

AU - Neuendorff, Melanie

AU - Hatherell, Avril

AU - Bernstein, Michael Jason

AU - Albensi, Benedict C.

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