Nickel-Catalyzed α-Carbonylalkylarylation of Vinylarenes: Expedient Access to γ,γ-Diarylcarbonyl and Aryltetralone Derivatives

K. C. Shekhar, Roshan K. Dhungana, Namrata Khanal, Ramesh Giri

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

We report a Ni-catalyzed regioselective α-carbonylalkylarylation of vinylarenes with α-halocarbonyl compounds and arylzinc reagents. The reaction works with primary, secondary, and tertiary α-halocarbonyl molecules, and electronically varied arylzinc reagents. The reaction generates γ,γ-diarylcarbonyl derivatives with α-secondary, tertiary, and quaternary carbon centers. The products can be readily converted to aryltetralones, including a precursor to Zoloft, an antidepressant drug.

Original languageEnglish (US)
Pages (from-to)8047-8051
Number of pages5
JournalAngewandte Chemie - International Edition
Volume59
Issue number21
DOIs
StatePublished - May 18 2020

All Science Journal Classification (ASJC) codes

  • Catalysis
  • Chemistry(all)

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