Nicotine Enhances Context Learning but Not Context-Shock Associative Learning

Justin W. Kenney, Thomas J. Gould

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Nicotine has been found to enhance learning in a variety of tasks, including contextual fear conditioning. During contextual fear conditioning animals have to learn the context and associate the context with an unconditioned stimulus (footshock). As both of these types of learning co-occur during fear conditioning, it is not clear whether nicotine enhances one or both of these types of learning. To tease these two forms of learning apart, the authors made use of the context preexposure facilitation effect (CPFE). Acquisition of the CPFE requires that contextual and context-shock learning occurs on separate days, allowing for their individual manipulation. Nicotine (0.09 mg/kg) administered prior to contextual learning and retrieval enhanced the CPFE whereas administration prior to context-shock learning and retrieval had no effect. Thus, nicotine enhances contextual learning but not context-shock associative learning. Finally, the results are discussed in terms of a theory of how nicotine could alter hippocampal-cortical-amygdala interactions to facilitate contextual learning.

Original languageEnglish (US)
Pages (from-to)1158-1165
Number of pages8
JournalBehavioral Neuroscience
Volume122
Issue number5
DOIs
StatePublished - Oct 1 2008

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Nicotine
Shock
Learning
Fear

All Science Journal Classification (ASJC) codes

  • Behavioral Neuroscience

Cite this

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Nicotine Enhances Context Learning but Not Context-Shock Associative Learning. / Kenney, Justin W.; Gould, Thomas J.

In: Behavioral Neuroscience, Vol. 122, No. 5, 01.10.2008, p. 1158-1165.

Research output: Contribution to journalArticle

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