Nicotinic receptors in the dorsal and ventral hippocampus differentially modulate contextual fear conditioning

Justin W. Kenney, Jonathan D. Raybuck, Thomas J. Gould

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

Nicotine administration alters various forms of hippocampus-dependent learning and memory. Increasing work has found that the dorsal and ventral hippocampus differentially contribute to multiple behaviors. Thus, the present study examined whether the effects of nicotine in the dorsal and ventral hippocampus have distinct influences on contextual fear learning in male C57BL/6J mice. Direct infusion of nicotine into the dorsal hippocampus resulted in an enhancement of contextual fear learning, whereas nicotine infused into the ventral hippocampus resulted in deficits. Nicotine infusions into the ventral hippocampus did not alter hippocampus-independent cued fear conditioning or time spent in the open arm of the elevated plus maze, a measure of anxiety, suggesting that the effects are due to alterations in contextual learning and not other general processes. Finally, results from using direct infusions of MLA, a low-affinity α7 nicotinic acetylcholine receptor (nAChR) antagonist, in conjunction with systemic nicotine, provide evidence that α7-nAChRs in the ventral hippocampus mediate the detrimental effect of ventral hippocampal nicotine on contextual fear learning. These results suggest that with systemic nicotine administration, competition exists between the dorsal and ventral hippocampus for behavioral control over contextual learning.

Original languageEnglish (US)
Pages (from-to)1681-1690
Number of pages10
JournalHippocampus
Volume22
Issue number8
DOIs
StatePublished - Aug 1 2012

Fingerprint

Nicotinic Receptors
Fear
Nicotine
Hippocampus
Learning
Conditioning (Psychology)
Cholinergic Antagonists
Inbred C57BL Mouse
Anxiety

All Science Journal Classification (ASJC) codes

  • Cognitive Neuroscience

Cite this

@article{58d3f27fec024f12adbc8504508dafbb,
title = "Nicotinic receptors in the dorsal and ventral hippocampus differentially modulate contextual fear conditioning",
abstract = "Nicotine administration alters various forms of hippocampus-dependent learning and memory. Increasing work has found that the dorsal and ventral hippocampus differentially contribute to multiple behaviors. Thus, the present study examined whether the effects of nicotine in the dorsal and ventral hippocampus have distinct influences on contextual fear learning in male C57BL/6J mice. Direct infusion of nicotine into the dorsal hippocampus resulted in an enhancement of contextual fear learning, whereas nicotine infused into the ventral hippocampus resulted in deficits. Nicotine infusions into the ventral hippocampus did not alter hippocampus-independent cued fear conditioning or time spent in the open arm of the elevated plus maze, a measure of anxiety, suggesting that the effects are due to alterations in contextual learning and not other general processes. Finally, results from using direct infusions of MLA, a low-affinity α7 nicotinic acetylcholine receptor (nAChR) antagonist, in conjunction with systemic nicotine, provide evidence that α7-nAChRs in the ventral hippocampus mediate the detrimental effect of ventral hippocampal nicotine on contextual fear learning. These results suggest that with systemic nicotine administration, competition exists between the dorsal and ventral hippocampus for behavioral control over contextual learning.",
author = "Kenney, {Justin W.} and Raybuck, {Jonathan D.} and Gould, {Thomas J.}",
year = "2012",
month = "8",
day = "1",
doi = "10.1002/hipo.22003",
language = "English (US)",
volume = "22",
pages = "1681--1690",
journal = "Hippocampus",
issn = "1050-9631",
publisher = "Wiley-Liss Inc.",
number = "8",

}

Nicotinic receptors in the dorsal and ventral hippocampus differentially modulate contextual fear conditioning. / Kenney, Justin W.; Raybuck, Jonathan D.; Gould, Thomas J.

In: Hippocampus, Vol. 22, No. 8, 01.08.2012, p. 1681-1690.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Nicotinic receptors in the dorsal and ventral hippocampus differentially modulate contextual fear conditioning

AU - Kenney, Justin W.

AU - Raybuck, Jonathan D.

AU - Gould, Thomas J.

PY - 2012/8/1

Y1 - 2012/8/1

N2 - Nicotine administration alters various forms of hippocampus-dependent learning and memory. Increasing work has found that the dorsal and ventral hippocampus differentially contribute to multiple behaviors. Thus, the present study examined whether the effects of nicotine in the dorsal and ventral hippocampus have distinct influences on contextual fear learning in male C57BL/6J mice. Direct infusion of nicotine into the dorsal hippocampus resulted in an enhancement of contextual fear learning, whereas nicotine infused into the ventral hippocampus resulted in deficits. Nicotine infusions into the ventral hippocampus did not alter hippocampus-independent cued fear conditioning or time spent in the open arm of the elevated plus maze, a measure of anxiety, suggesting that the effects are due to alterations in contextual learning and not other general processes. Finally, results from using direct infusions of MLA, a low-affinity α7 nicotinic acetylcholine receptor (nAChR) antagonist, in conjunction with systemic nicotine, provide evidence that α7-nAChRs in the ventral hippocampus mediate the detrimental effect of ventral hippocampal nicotine on contextual fear learning. These results suggest that with systemic nicotine administration, competition exists between the dorsal and ventral hippocampus for behavioral control over contextual learning.

AB - Nicotine administration alters various forms of hippocampus-dependent learning and memory. Increasing work has found that the dorsal and ventral hippocampus differentially contribute to multiple behaviors. Thus, the present study examined whether the effects of nicotine in the dorsal and ventral hippocampus have distinct influences on contextual fear learning in male C57BL/6J mice. Direct infusion of nicotine into the dorsal hippocampus resulted in an enhancement of contextual fear learning, whereas nicotine infused into the ventral hippocampus resulted in deficits. Nicotine infusions into the ventral hippocampus did not alter hippocampus-independent cued fear conditioning or time spent in the open arm of the elevated plus maze, a measure of anxiety, suggesting that the effects are due to alterations in contextual learning and not other general processes. Finally, results from using direct infusions of MLA, a low-affinity α7 nicotinic acetylcholine receptor (nAChR) antagonist, in conjunction with systemic nicotine, provide evidence that α7-nAChRs in the ventral hippocampus mediate the detrimental effect of ventral hippocampal nicotine on contextual fear learning. These results suggest that with systemic nicotine administration, competition exists between the dorsal and ventral hippocampus for behavioral control over contextual learning.

UR - http://www.scopus.com/inward/record.url?scp=84863782200&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863782200&partnerID=8YFLogxK

U2 - 10.1002/hipo.22003

DO - 10.1002/hipo.22003

M3 - Article

C2 - 22271264

AN - SCOPUS:84863782200

VL - 22

SP - 1681

EP - 1690

JO - Hippocampus

JF - Hippocampus

SN - 1050-9631

IS - 8

ER -