Nitric oxide synthase (NOS) expression in the myenteric plexus of streptozotocin-diabetic rats

Helena F. Wrzos, Amgelene Cruz, Rohini Polavarapu, Debbie Shearer, Ann Ouyang

Research output: Contribution to journalArticle

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Abstract

Nitric oxide (NO) is an important inhibitory neurotransmitter in the gut. Alterations in NO mediated responses have been described in diabetic animals. The presence of nitric oxide synthase (NOS) reflects the potential for NO synthesis and is found in neurons in the myenteric plexus. The aim of this study was to determine changes in nitric oxide synthase (NOS) expression in the myenteric plexus of the gastrointestinal tract of diabetic rats at three months of streptozotocin-induced diabetes, compared to age matched controls, using immunohistochemistry. Diabetic animals showed a decrease in NOS expression in the antrum, with 59.1 ± 7.3% of neurons being positive for NOS in diabetes compared to 81.2 ± 4.7% in controls (P < 0.05). NOS expression in duodenum, ileum, and colon of diabetic animals was not statistically different from controls. Decreased expression of NOS in antrum may contribute to altered gastric emptying observed in diabetics.

Original languageEnglish (US)
Pages (from-to)2106-2110
Number of pages5
JournalDigestive Diseases and Sciences
Volume42
Issue number10
DOIs
StatePublished - Jan 1 1997

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Myenteric Plexus
Streptozocin
Nitric Oxide Synthase
Nitric Oxide
Neurons
Experimental Diabetes Mellitus
Gastric Emptying
Ileum
Duodenum
Neurotransmitter Agents
Gastrointestinal Tract
Colon
Immunohistochemistry

All Science Journal Classification (ASJC) codes

  • Physiology
  • Gastroenterology

Cite this

Wrzos, Helena F. ; Cruz, Amgelene ; Polavarapu, Rohini ; Shearer, Debbie ; Ouyang, Ann. / Nitric oxide synthase (NOS) expression in the myenteric plexus of streptozotocin-diabetic rats. In: Digestive Diseases and Sciences. 1997 ; Vol. 42, No. 10. pp. 2106-2110.
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Nitric oxide synthase (NOS) expression in the myenteric plexus of streptozotocin-diabetic rats. / Wrzos, Helena F.; Cruz, Amgelene; Polavarapu, Rohini; Shearer, Debbie; Ouyang, Ann.

In: Digestive Diseases and Sciences, Vol. 42, No. 10, 01.01.1997, p. 2106-2110.

Research output: Contribution to journalArticle

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AU - Cruz, Amgelene

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