NMR-Based Metabolomics and Its Application in Drug Metabolism and Cancer Research

Limin Zhang, Emmanuel Hatzakis, Andrew D. Patterson

Research output: Contribution to journalReview article

7 Scopus citations

Abstract

Purpose of Review: In this review, the contribution of NMR to the metabolomics field will be discussed—particularly as it relates to cancer and drug metabolism research. An overview of the typical NMR metabolomic experiment will be presented while emphasizing important caveats ranging from experimental design to data interpretation. Recent Findings: Despite some of the drawbacks of NMR, including reduced sensitivity compared to mass spectrometry-based approaches, NMR-based metabolomic approaches have provided considerable insight into drug and cancer metabolism. Advances in flux analysis based on the strategic use of isotopes have generated unique perspectives of cancer from the cellular and tissue levels. Summary: Combined with other “omics” tools, including genomics, proteomics, and transcriptomics, metabolomic analysis completes the holistic view of metabolism. Many of these NMR-based approaches are likely to find their way into the clinic and become a common diagnostic tool.

Original languageEnglish (US)
Pages (from-to)231-240
Number of pages10
JournalCurrent Pharmacology Reports
Volume2
Issue number5
DOIs
StatePublished - Oct 1 2016

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All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Genetics
  • Pharmacology
  • Drug Discovery

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