NMR solution structures of adducts derived from the binding of polycyclic aromatic diol epoxides to DNA

M. Cosman, B. E. Hingerty, S. Amin, S. Broyde, N. E. Geacintov, D. J. Patel

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Abstract

Site-specifically modified oligonucleotides were derived from the reactions of stereoisomeric polycyclic aromatic diol epoxide metabolite model compounds with oligonucleotides of defined base composition and sequence. The NMR solution structures of ten different adducts studied so far are briefly described, and it is shown that stereochemical factors and the nature of the oligonucleotide context of the complementary strands, exert a powerful influence on the conformational features of these adducts.

Original languageEnglish (US)
Pages (from-to)153-160
Number of pages8
JournalPolycyclic Aromatic Compounds
Volume10
Issue number1-4
DOIs
Publication statusPublished - Jan 1 1996

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All Science Journal Classification (ASJC) codes

  • Polymers and Plastics
  • Organic Chemistry
  • Materials Chemistry

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