No association between general cognitive ability and the A1 allele of the D2 dopamine receptor gene

Stephen A. Petrill, Robert Plomin, Gerald E. McClearn, Deborah L. Smith, Sylvia Vignetti, Michael J. Chorney, Karen Chorney, Lee A. Thompson, Douglas K. Detterman, Camilla Benbow, David Lubinski, Joanna Daniels, Michael Owen, Peter McGuffin

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29 Scopus citations

Abstract

Berman and Noble (1995) reported significantly reduced visuospatial performance in children with the TAQI A1 allele of the D2 dopamine receptor (DRD2) gene. Given that visuospatial performance loads highly on an unrotated principal component indexing general cognitive ability, we tested the association between DRD2 and WISC-R IQ comparing 51 high-IQ, 51 average-IQ, and 35 low-IQ children in the IQ Quantitative Trait Loci (QTL) Project. No statistically significant association between the TAQI A DRD2 alleles and IQ was found. Given that a statistically significant portion of genetic variance for specific cognitive abilities is independent of general cognitive ability, it is possible that the TAQI DRD2 association is specific to visuospatial performance and independent of general cognitive ability.

Original languageEnglish (US)
Pages (from-to)29-31
Number of pages3
JournalBehavior Genetics
Volume27
Issue number1
DOIs
StatePublished - Jan 1 1997

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Genetics(clinical)

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    Petrill, S. A., Plomin, R., McClearn, G. E., Smith, D. L., Vignetti, S., Chorney, M. J., Chorney, K., Thompson, L. A., Detterman, D. K., Benbow, C., Lubinski, D., Daniels, J., Owen, M., & McGuffin, P. (1997). No association between general cognitive ability and the A1 allele of the D2 dopamine receptor gene. Behavior Genetics, 27(1), 29-31. https://doi.org/10.1023/A:1025659124405