No association between novelty seeking and dopamine D4 receptor (D4DR) exon III seven repeat alleles in Baltimore longitudinal study of aging participants

David John Vandenbergh, A. B. Zonderman, J. Wang, G. R. Uhl, P. T. Costa

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

Recent studies by Ebstein et al1 and Benjamin et al2 found associations between long repeat polymorphisms in the D4 dopamine receptor gene (D4DR) and individual variation in a human personality trait, identified as 'Novelty Seeking'(NS). Ebstein et al used the Tridimensional Personality Questionnaire (TPQ)3 to measure NS scores; Benjamin et al used the Revised NEO Personality Inventory (NEO-PI-R)4 to estimate NS scores. However, Malhotra et al5 failed to replicate the association between the direct measure of NS using the TPQ and the long alleles of the D4DR genotypes in two Finnish samples. In an attempt to confirm the association found by Benjamin et al using NEO-PI-R estimated NS, the present study used an alternative design extreme groups strategy to select high and low novelty seeking research volunteers from the Baltimore Longitudinal Study of Aging (BLSA).6 There were no significant associations between long alleles (7-repeat allele) and high novelty seeking groups. The findings of Ebstein and colleagues and those of Benjamin and colleagues do not generalize to this American middle-aged, mixed-gender sample, a conclusion also consistent with the findings of a recent Swedish study.7 Demographic factors such as the age and gender composition of the samples are important sources of variation in allelic association studies and future research must carefully address whether the D4DR genetic polymorphisms vary substantially across demographic groups.

Original languageEnglish (US)
Pages (from-to)417-419
Number of pages3
JournalMolecular Psychiatry
Volume2
Issue number5
DOIs
StatePublished - Jan 1 1997

Fingerprint

Dopamine D4 Receptors
Baltimore
Longitudinal Studies
Personality
Exons
Personality Inventory
Alleles
Demography
Genes
Genetic Polymorphisms
Volunteers
Genotype
Research
Surveys and Questionnaires

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Psychiatry and Mental health
  • Cellular and Molecular Neuroscience

Cite this

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title = "No association between novelty seeking and dopamine D4 receptor (D4DR) exon III seven repeat alleles in Baltimore longitudinal study of aging participants",
abstract = "Recent studies by Ebstein et al1 and Benjamin et al2 found associations between long repeat polymorphisms in the D4 dopamine receptor gene (D4DR) and individual variation in a human personality trait, identified as 'Novelty Seeking'(NS). Ebstein et al used the Tridimensional Personality Questionnaire (TPQ)3 to measure NS scores; Benjamin et al used the Revised NEO Personality Inventory (NEO-PI-R)4 to estimate NS scores. However, Malhotra et al5 failed to replicate the association between the direct measure of NS using the TPQ and the long alleles of the D4DR genotypes in two Finnish samples. In an attempt to confirm the association found by Benjamin et al using NEO-PI-R estimated NS, the present study used an alternative design extreme groups strategy to select high and low novelty seeking research volunteers from the Baltimore Longitudinal Study of Aging (BLSA).6 There were no significant associations between long alleles (7-repeat allele) and high novelty seeking groups. The findings of Ebstein and colleagues and those of Benjamin and colleagues do not generalize to this American middle-aged, mixed-gender sample, a conclusion also consistent with the findings of a recent Swedish study.7 Demographic factors such as the age and gender composition of the samples are important sources of variation in allelic association studies and future research must carefully address whether the D4DR genetic polymorphisms vary substantially across demographic groups.",
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No association between novelty seeking and dopamine D4 receptor (D4DR) exon III seven repeat alleles in Baltimore longitudinal study of aging participants. / Vandenbergh, David John; Zonderman, A. B.; Wang, J.; Uhl, G. R.; Costa, P. T.

In: Molecular Psychiatry, Vol. 2, No. 5, 01.01.1997, p. 417-419.

Research output: Contribution to journalArticle

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