No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer

Lynette S. Phillips; Cheryl L. Thompson; Alona Merkulova; Sarah J. Plummer; Thomas C. Tucker; Graham Casey; Li Li

doi:10.3748/wjg.15.3771

No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer

Lynette S. Phillips, Cheryl L. Thompson, Alona Merkulova, Sarah J. Plummer, Thomas C. Tucker, Graham Casey, Li Li

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

AIM: To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer. METHODS: We utilized a population-based case-control study of incident colon cancer individuals (n = 421) and controls (n = 483) aged ≥ 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene. RESULTS: None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer. CONCLUSION: Our study does not support PTEN as a colon cancer susceptibility gene.

Original language	English (US)
Pages (from-to)	3771-3775
Number of pages	5
Journal	World journal of gastroenterology
Volume	15
Issue number	30
DOIs	https://doi.org/10.3748/wjg.15.3771
State	Published - 2009

All Science Journal Classification (ASJC) codes

Gastroenterology

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title = "No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer",

abstract = "AIM: To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer. METHODS: We utilized a population-based case-control study of incident colon cancer individuals (n = 421) and controls (n = 483) aged ≥ 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene. RESULTS: None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer. CONCLUSION: Our study does not support PTEN as a colon cancer susceptibility gene.",

author = "Phillips, {Lynette S.} and Thompson, {Cheryl L.} and Alona Merkulova and Plummer, {Sarah J.} and Tucker, {Thomas C.} and Graham Casey and Li Li",

year = "2009",

doi = "10.3748/wjg.15.3771",

language = "English (US)",

volume = "15",

pages = "3771--3775",

journal = "World Journal of Gastroenterology",

issn = "1007-9327",

publisher = "WJG Press",

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TY - JOUR

T1 - No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer

AU - Phillips, Lynette S.

AU - Thompson, Cheryl L.

AU - Merkulova, Alona

AU - Plummer, Sarah J.

AU - Tucker, Thomas C.

AU - Casey, Graham

AU - Li, Li

PY - 2009

Y1 - 2009

N2 - AIM: To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer. METHODS: We utilized a population-based case-control study of incident colon cancer individuals (n = 421) and controls (n = 483) aged ≥ 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene. RESULTS: None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer. CONCLUSION: Our study does not support PTEN as a colon cancer susceptibility gene.

AB - AIM: To investigate the association between single nucleotide polymorphisms (SNPs) in the phosphatase and tensin homolog (PTEN) tumor suppressor gene and risk of colon cancer. METHODS: We utilized a population-based case-control study of incident colon cancer individuals (n = 421) and controls (n = 483) aged ≥ 30 years to conduct a comprehensive tagSNP association analysis of the PTEN gene. RESULTS: None of the PTEN SNPs were statistically significantly associated with colon cancer when controlled for age, gender, and race, or when additionally adjusted for other known risk factors (P > 0.05). Haplotype analyses similarly showed no association between the PTEN gene and colon cancer. CONCLUSION: Our study does not support PTEN as a colon cancer susceptibility gene.

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No association between phosphatase and tensin homolog genetic polymorphisms and colon cancer

Abstract

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