No association between Vitamin D intake, VDR polymorphisms, and colorectal cancer in a population-based case-control study

Joseph H. Ashmore, Carla J. Gallagher, Samuel M. Lesko, Joshua E. Muscat, Terryl J. Hartman, Philip Lazarus

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Background: Epidemiologic evidence indicates that greater intakes of vitamin D may decrease the risk of colorectal cancer. Variants in the vitamin D receptor (VDR) gene have the potential to modify associations between vitamin D intake and colorectal cancer. Methods: Associations between intakes of vitamin D and colorectal cancer were studied in a large case-control study conducted in central and northeastern Pennsylvania including 1,012 cases with histologically confirmed colorectal cancer and 1,080 population-based controls. Associations between 35 tag SNPs encompassing the VDR gene and risk for colorectal cancer as well as gene-diet associations were also assessed among a subset of the population (770 controls, 710 cases). Results: No significant trends were observed between vitamin D intake and colorectal cancer risk. After adjustment for multiple comparisons, none of the SNPs or haplotypes within the VDR gene were associated with colorectal cancer. There were also no interactions between dietary factors and variants in the entire VDR gene. Conclusions: Overall, results from this study suggest that vitamin D intake and variants in the VDR gene have little effect on risk for colorectal cancer. Impact: Increasing vitamin D intake from the diet may not result in decreasing the incidence of colorectal cancer.

Original languageEnglish (US)
Pages (from-to)1635-1637
Number of pages3
JournalCancer Epidemiology Biomarkers and Prevention
Volume24
Issue number10
DOIs
StatePublished - Oct 1 2015

    Fingerprint

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology

Cite this