No evidence for intra-segment recombination of 2009 H1N1 influenza virus in swine

Maciej F. Boni; Gavin J.D. Smith; Edward C. Holmes; Dhanasekaran Vijaykrishna

doi:10.1016/j.gene.2011.10.041

No evidence for intra-segment recombination of 2009 H1N1 influenza virus in swine

Maciej F. Boni, Gavin J.D. Smith, Edward C. Holmes, Dhanasekaran Vijaykrishna

Research output: Contribution to journal › Letter › peer-review

12 Scopus citations

Abstract

Hao (2011) reported that the PB2 genes of three swine influenza A viruses were likely generated through homologous recombination between two closely related parental strains. However, we show that Hao's observation is an artifact of incorrect taxon sampling arising through the lack of an appropriate evolutionary context. Through rigorous phylogenetic analyses we explain the evolutionary origins of these stains and confirm the lack of any statistical support for intra-segmental recombination.

Original language	English (US)
Pages (from-to)	242-245
Number of pages	4
Journal	Gene
Volume	494
Issue number	2
DOIs	https://doi.org/10.1016/j.gene.2011.10.041
State	Published - Feb 25 2012

All Science Journal Classification (ASJC) codes

Genetics

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10.1016/j.gene.2011.10.041

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title = "No evidence for intra-segment recombination of 2009 H1N1 influenza virus in swine",

abstract = "Hao (2011) reported that the PB2 genes of three swine influenza A viruses were likely generated through homologous recombination between two closely related parental strains. However, we show that Hao's observation is an artifact of incorrect taxon sampling arising through the lack of an appropriate evolutionary context. Through rigorous phylogenetic analyses we explain the evolutionary origins of these stains and confirm the lack of any statistical support for intra-segmental recombination.",

author = "Boni, {Maciej F.} and Smith, {Gavin J.D.} and Holmes, {Edward C.} and Dhanasekaran Vijaykrishna",

note = "Funding Information: We acknowledge support from Wellcome Trust grant 089276/B/09/Z (M.F.B), NIAID contract HHSN266200700005C (G.J.D.S.), the Agency for Science, Technology and Research and the Ministry of Health, Singapore (G.J.D.S. and D.V.).",

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T1 - No evidence for intra-segment recombination of 2009 H1N1 influenza virus in swine

AU - Boni, Maciej F.

AU - Smith, Gavin J.D.

AU - Holmes, Edward C.

AU - Vijaykrishna, Dhanasekaran

N1 - Funding Information: We acknowledge support from Wellcome Trust grant 089276/B/09/Z (M.F.B), NIAID contract HHSN266200700005C (G.J.D.S.), the Agency for Science, Technology and Research and the Ministry of Health, Singapore (G.J.D.S. and D.V.).

PY - 2012/2/25

Y1 - 2012/2/25

N2 - Hao (2011) reported that the PB2 genes of three swine influenza A viruses were likely generated through homologous recombination between two closely related parental strains. However, we show that Hao's observation is an artifact of incorrect taxon sampling arising through the lack of an appropriate evolutionary context. Through rigorous phylogenetic analyses we explain the evolutionary origins of these stains and confirm the lack of any statistical support for intra-segmental recombination.

AB - Hao (2011) reported that the PB2 genes of three swine influenza A viruses were likely generated through homologous recombination between two closely related parental strains. However, we show that Hao's observation is an artifact of incorrect taxon sampling arising through the lack of an appropriate evolutionary context. Through rigorous phylogenetic analyses we explain the evolutionary origins of these stains and confirm the lack of any statistical support for intra-segmental recombination.

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No evidence for intra-segment recombination of 2009 H1N1 influenza virus in swine

Abstract

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