Noise in nanopore sensors: Sources, models, reduction, and benchmarking

Shengfa Liang, Feibin Xiang, Zifan Tang, Reza Nouri, Xiaodong He, Ming Dong, Weihua Guan

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Label-free nanopore sensors have emerged as a new generation technology of DNA sequencing and have been widely used for single molecule analysis. Since the first α-hemolysin biological nanopore, various types of nanopores made of different materials have been under extensive development. Noise represents a common challenge among all types of nanopore sensors. The nanopore noise can be decomposed into four components in the frequency domain (1/f noise, white noise, dielectric noise, and amplifier noise). In this work, we reviewed andsummarizedthephysicalmodels, origins, andreductionmethodsforeachofthesenoisecomponents.Forthe first time, we quantitatively benchmarked the root mean square (RMS) noise levels for different types of nanopores, demonstrating a clear material-dependent RMS noise. We anticipate this review article will enhance theunderstandingofnanoporesensor noisesandprovideaninformativetutorialfordeveloping futurenanopore sensors with a high signal-to-noise ratio.

Original languageEnglish (US)
Pages (from-to)9-17
Number of pages9
JournalNami Jishu yu Jingmi Gongcheng/Nanotechnology and Precision Engineering
Issue number1
StatePublished - Mar 1 2020

All Science Journal Classification (ASJC) codes

  • Instrumentation
  • Mechanical Engineering
  • Industrial and Manufacturing Engineering


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