Non-hazardous synthesis of isocephosphorin intermediates via α-vinylamino-β-lactams

Ajay K. Bose, Maghar S. Manhas, Shanti G. Amin, Jagdish C. Kapur, J. Kreder, L. Mukkavilli, Bhagat Ram, John E. Vincent

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

The reaction of a Schiff Base derived from veratrylamine and cinnamaldehyde with (α-methyl-β-alkoxycarbonyl)-vinylamino acetic acid (from glycine and an acetoacetate ester) in presence of a chloroformate ester and triethylamine constitutes a safe synthesis of α-vinylamino β-lactams that can be converted by literature methods to known intermediates for the synthesis of isocephalosporins and analogs.

Original languageEnglish (US)
Pages (from-to)2771-2774
Number of pages4
JournalTetrahedron Letters
Volume20
Issue number30
DOIs
StatePublished - 1979

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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