Non-high-density lipoprotein cholesterol vs low-density lipoprotein cholesterol as a risk factor for ischemic stroke: A result from the Kailuan study

Jianwei Wu, Shengyun Chen, Liping Liu, Xiang Gao, Yong Zhou, Chunxue Wang, Qian Zhang, Anxin Wang, Mohammed Hussain, Baoying Sun, Shouling Wu, Xingquan Zhao

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Abstract

Objectives: To compare the predictive value of serum low-density lipoprotein (LDL) cholesterol and non-high-density lipoprotein (non-HDL) cholesterol levels for ischemic stroke in the Chinese population. Methods: We performed a four-year cohort study of 95 778 men and women, aged 18-98 years, selected from the Kailuan study (2006-2007). Baseline LDL cholesterol levels were estimated using direct test method. Total cholesterol levels were estimated using endpoint test method. The predictive values of LDL cholesterol and non-HDL cholesterol for ischemic stroke were compared. Results: During the follow-up period, there were 1153 incident cases of ischemic stroke. The hazard ratio (HR) for ischemic stroke in the top quintile of LDL cholesterol was the highest among five quintiles (HR: 1.25; 95% confidence interval (CI), 1.01-1.53). The HR in the top quintile of non-HDL cholesterol for ischemic stroke was also the highest among five quintiles (HR: 1.53; 95% CI, 1.24-1.88). Analysis of trends showed a significant positive relationship between ischemic stroke incidence and serum LDL cholesterol level, and non-HDL cholesterol level, respectively (both P < 0.05). The area under the curve of LDL cholesterol and non-HDL cholesterol for ischemic stroke was 0.51 and 0.56, respectively (P < 0.05 for the difference). Conclusions: Serum Non-HDL cholesterol level is a stronger predictor for the risk of ischemic stroke than serum LDL cholesterol level in the Chinese population.

Original languageEnglish (US)
Pages (from-to)505-511
Number of pages7
JournalNeurological Research
Volume35
Issue number5
DOIs
StatePublished - Jun 1 2013

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LDL Cholesterol
Stroke
Serum
Cholesterol
Confidence Intervals
lipoprotein cholesterol
Population
Area Under Curve
Cohort Studies
Incidence

All Science Journal Classification (ASJC) codes

  • Neurology
  • Clinical Neurology

Cite this

Wu, Jianwei ; Chen, Shengyun ; Liu, Liping ; Gao, Xiang ; Zhou, Yong ; Wang, Chunxue ; Zhang, Qian ; Wang, Anxin ; Hussain, Mohammed ; Sun, Baoying ; Wu, Shouling ; Zhao, Xingquan. / Non-high-density lipoprotein cholesterol vs low-density lipoprotein cholesterol as a risk factor for ischemic stroke : A result from the Kailuan study. In: Neurological Research. 2013 ; Vol. 35, No. 5. pp. 505-511.
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abstract = "Objectives: To compare the predictive value of serum low-density lipoprotein (LDL) cholesterol and non-high-density lipoprotein (non-HDL) cholesterol levels for ischemic stroke in the Chinese population. Methods: We performed a four-year cohort study of 95 778 men and women, aged 18-98 years, selected from the Kailuan study (2006-2007). Baseline LDL cholesterol levels were estimated using direct test method. Total cholesterol levels were estimated using endpoint test method. The predictive values of LDL cholesterol and non-HDL cholesterol for ischemic stroke were compared. Results: During the follow-up period, there were 1153 incident cases of ischemic stroke. The hazard ratio (HR) for ischemic stroke in the top quintile of LDL cholesterol was the highest among five quintiles (HR: 1.25; 95{\%} confidence interval (CI), 1.01-1.53). The HR in the top quintile of non-HDL cholesterol for ischemic stroke was also the highest among five quintiles (HR: 1.53; 95{\%} CI, 1.24-1.88). Analysis of trends showed a significant positive relationship between ischemic stroke incidence and serum LDL cholesterol level, and non-HDL cholesterol level, respectively (both P < 0.05). The area under the curve of LDL cholesterol and non-HDL cholesterol for ischemic stroke was 0.51 and 0.56, respectively (P < 0.05 for the difference). Conclusions: Serum Non-HDL cholesterol level is a stronger predictor for the risk of ischemic stroke than serum LDL cholesterol level in the Chinese population.",
author = "Jianwei Wu and Shengyun Chen and Liping Liu and Xiang Gao and Yong Zhou and Chunxue Wang and Qian Zhang and Anxin Wang and Mohammed Hussain and Baoying Sun and Shouling Wu and Xingquan Zhao",
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Non-high-density lipoprotein cholesterol vs low-density lipoprotein cholesterol as a risk factor for ischemic stroke : A result from the Kailuan study. / Wu, Jianwei; Chen, Shengyun; Liu, Liping; Gao, Xiang; Zhou, Yong; Wang, Chunxue; Zhang, Qian; Wang, Anxin; Hussain, Mohammed; Sun, Baoying; Wu, Shouling; Zhao, Xingquan.

In: Neurological Research, Vol. 35, No. 5, 01.06.2013, p. 505-511.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Non-high-density lipoprotein cholesterol vs low-density lipoprotein cholesterol as a risk factor for ischemic stroke

T2 - A result from the Kailuan study

AU - Wu, Jianwei

AU - Chen, Shengyun

AU - Liu, Liping

AU - Gao, Xiang

AU - Zhou, Yong

AU - Wang, Chunxue

AU - Zhang, Qian

AU - Wang, Anxin

AU - Hussain, Mohammed

AU - Sun, Baoying

AU - Wu, Shouling

AU - Zhao, Xingquan

PY - 2013/6/1

Y1 - 2013/6/1

N2 - Objectives: To compare the predictive value of serum low-density lipoprotein (LDL) cholesterol and non-high-density lipoprotein (non-HDL) cholesterol levels for ischemic stroke in the Chinese population. Methods: We performed a four-year cohort study of 95 778 men and women, aged 18-98 years, selected from the Kailuan study (2006-2007). Baseline LDL cholesterol levels were estimated using direct test method. Total cholesterol levels were estimated using endpoint test method. The predictive values of LDL cholesterol and non-HDL cholesterol for ischemic stroke were compared. Results: During the follow-up period, there were 1153 incident cases of ischemic stroke. The hazard ratio (HR) for ischemic stroke in the top quintile of LDL cholesterol was the highest among five quintiles (HR: 1.25; 95% confidence interval (CI), 1.01-1.53). The HR in the top quintile of non-HDL cholesterol for ischemic stroke was also the highest among five quintiles (HR: 1.53; 95% CI, 1.24-1.88). Analysis of trends showed a significant positive relationship between ischemic stroke incidence and serum LDL cholesterol level, and non-HDL cholesterol level, respectively (both P < 0.05). The area under the curve of LDL cholesterol and non-HDL cholesterol for ischemic stroke was 0.51 and 0.56, respectively (P < 0.05 for the difference). Conclusions: Serum Non-HDL cholesterol level is a stronger predictor for the risk of ischemic stroke than serum LDL cholesterol level in the Chinese population.

AB - Objectives: To compare the predictive value of serum low-density lipoprotein (LDL) cholesterol and non-high-density lipoprotein (non-HDL) cholesterol levels for ischemic stroke in the Chinese population. Methods: We performed a four-year cohort study of 95 778 men and women, aged 18-98 years, selected from the Kailuan study (2006-2007). Baseline LDL cholesterol levels were estimated using direct test method. Total cholesterol levels were estimated using endpoint test method. The predictive values of LDL cholesterol and non-HDL cholesterol for ischemic stroke were compared. Results: During the follow-up period, there were 1153 incident cases of ischemic stroke. The hazard ratio (HR) for ischemic stroke in the top quintile of LDL cholesterol was the highest among five quintiles (HR: 1.25; 95% confidence interval (CI), 1.01-1.53). The HR in the top quintile of non-HDL cholesterol for ischemic stroke was also the highest among five quintiles (HR: 1.53; 95% CI, 1.24-1.88). Analysis of trends showed a significant positive relationship between ischemic stroke incidence and serum LDL cholesterol level, and non-HDL cholesterol level, respectively (both P < 0.05). The area under the curve of LDL cholesterol and non-HDL cholesterol for ischemic stroke was 0.51 and 0.56, respectively (P < 0.05 for the difference). Conclusions: Serum Non-HDL cholesterol level is a stronger predictor for the risk of ischemic stroke than serum LDL cholesterol level in the Chinese population.

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