Nonallelic gene conversion Is Not GC-biased in drosophila or primates

Raquel Assis, Alexey S. Kondrashov

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Gene conversion is the unidirectional transfer of genetic information between allelic (orthologous) or nonallelic (paralogous) DNA segments. Recently, there has been much interest in understanding how gene conversion shapes the nucleotide composition of the genomic landscape. A widely held hypothesis is that gene conversion is universally GCbiased. However, direct experimental evidence of this hypothesis is limited to a single study of meiotic crossovers in yeast. Although there have been a number of indirect studies of gene conversion, evidence of GC-biased replacements gathered from such studies can also be attributed to positive selection, which has the same evolutionary dynamics as biased gene conversion. Here, we apply a direct phylogenetic approach to examine nucleotide replacements produced by nonallelic gene conversion in Drosophila and primate genomes. We find no evidence for GC-biased gene conversion in either lineage, suggesting that previously observed GC biases may be due to positive selection rather than to biased gene conversion.

Original languageEnglish (US)
Pages (from-to)1291-1295
Number of pages5
JournalMolecular Biology and Evolution
Volume29
Issue number5
DOIs
StatePublished - May 1 2012

Fingerprint

Gene Conversion
gene conversion
primate
Primates
Drosophila
gene
Nucleotides
replacement
nucleotides
Cross-Over Studies
yeast
genomics
genome
Yeasts
Genome
yeasts
phylogenetics
DNA
phylogeny

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Molecular Biology
  • Genetics

Cite this

@article{5dad4c0e5b994fdd9384db32e0c53cf0,
title = "Nonallelic gene conversion Is Not GC-biased in drosophila or primates",
abstract = "Gene conversion is the unidirectional transfer of genetic information between allelic (orthologous) or nonallelic (paralogous) DNA segments. Recently, there has been much interest in understanding how gene conversion shapes the nucleotide composition of the genomic landscape. A widely held hypothesis is that gene conversion is universally GCbiased. However, direct experimental evidence of this hypothesis is limited to a single study of meiotic crossovers in yeast. Although there have been a number of indirect studies of gene conversion, evidence of GC-biased replacements gathered from such studies can also be attributed to positive selection, which has the same evolutionary dynamics as biased gene conversion. Here, we apply a direct phylogenetic approach to examine nucleotide replacements produced by nonallelic gene conversion in Drosophila and primate genomes. We find no evidence for GC-biased gene conversion in either lineage, suggesting that previously observed GC biases may be due to positive selection rather than to biased gene conversion.",
author = "Raquel Assis and Kondrashov, {Alexey S.}",
year = "2012",
month = "5",
day = "1",
doi = "10.1093/molbev/msr304",
language = "English (US)",
volume = "29",
pages = "1291--1295",
journal = "Molecular Biology and Evolution",
issn = "0737-4038",
publisher = "Oxford University Press",
number = "5",

}

Nonallelic gene conversion Is Not GC-biased in drosophila or primates. / Assis, Raquel; Kondrashov, Alexey S.

In: Molecular Biology and Evolution, Vol. 29, No. 5, 01.05.2012, p. 1291-1295.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Nonallelic gene conversion Is Not GC-biased in drosophila or primates

AU - Assis, Raquel

AU - Kondrashov, Alexey S.

PY - 2012/5/1

Y1 - 2012/5/1

N2 - Gene conversion is the unidirectional transfer of genetic information between allelic (orthologous) or nonallelic (paralogous) DNA segments. Recently, there has been much interest in understanding how gene conversion shapes the nucleotide composition of the genomic landscape. A widely held hypothesis is that gene conversion is universally GCbiased. However, direct experimental evidence of this hypothesis is limited to a single study of meiotic crossovers in yeast. Although there have been a number of indirect studies of gene conversion, evidence of GC-biased replacements gathered from such studies can also be attributed to positive selection, which has the same evolutionary dynamics as biased gene conversion. Here, we apply a direct phylogenetic approach to examine nucleotide replacements produced by nonallelic gene conversion in Drosophila and primate genomes. We find no evidence for GC-biased gene conversion in either lineage, suggesting that previously observed GC biases may be due to positive selection rather than to biased gene conversion.

AB - Gene conversion is the unidirectional transfer of genetic information between allelic (orthologous) or nonallelic (paralogous) DNA segments. Recently, there has been much interest in understanding how gene conversion shapes the nucleotide composition of the genomic landscape. A widely held hypothesis is that gene conversion is universally GCbiased. However, direct experimental evidence of this hypothesis is limited to a single study of meiotic crossovers in yeast. Although there have been a number of indirect studies of gene conversion, evidence of GC-biased replacements gathered from such studies can also be attributed to positive selection, which has the same evolutionary dynamics as biased gene conversion. Here, we apply a direct phylogenetic approach to examine nucleotide replacements produced by nonallelic gene conversion in Drosophila and primate genomes. We find no evidence for GC-biased gene conversion in either lineage, suggesting that previously observed GC biases may be due to positive selection rather than to biased gene conversion.

UR - http://www.scopus.com/inward/record.url?scp=84862899535&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84862899535&partnerID=8YFLogxK

U2 - 10.1093/molbev/msr304

DO - 10.1093/molbev/msr304

M3 - Article

VL - 29

SP - 1291

EP - 1295

JO - Molecular Biology and Evolution

JF - Molecular Biology and Evolution

SN - 0737-4038

IS - 5

ER -