Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3

Dongwon Kim, Ruosi Chen, Mary Sheu, Noori Kim, Sooah Kim, Nasif Islam, Eric M. Wier, Gaofeng Wang, Ang Li, Angela Park, Wooyang Son, Benjamin Evans, Victoria Yu, Vicky P. Prizmic, Eugene Oh, Zixiao Wang, Jianshi Yu, Weiliang Huang, Nathan K. Archer, Zhiqi HuNashay Clemetson, Amanda Nelson, Anna Chien, Ginette A. Okoye, Lloyd S. Miller, Gabriel Ghiaur, Sewon Kang, Jace W. Jones, Maureen A. Kane, Luis A. Garza

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

How developmental programs reactivate in regeneration is a fundamental question in biology. We addressed this question through the study of Wound Induced Hair follicle Neogenesis (WIHN), an adult organogenesis model where stem cells regenerate de novo hair follicles following deep wounding. The exact mechanism is uncertain. Here we show that self-noncoding dsRNA activates the anti-viral receptor toll like receptor 3 (TLR3) to induce intrinsic retinoic acid (RA) synthesis in a pattern that predicts new hair follicle formation after wounding in mice. Additionally, in humans, rejuvenation lasers induce gene expression signatures for dsRNA and RA, with measurable increases in intrinsic RA synthesis. These results demonstrate a potent stimulus for RA synthesis by non-coding dsRNA, relevant to their broad functions in development and immunity.

Original languageEnglish (US)
Article number2811
JournalNature communications
Volume10
Issue number1
DOIs
StatePublished - Dec 1 2019

Fingerprint

Toll-Like Receptor 3
Hair Follicle
hair
Tretinoin
regeneration
Regeneration
acids
synthesis
Rejuvenation
Organogenesis
stem cells
gene expression
immunity
Stem cells
biology
Transcriptome
Gene expression
stimuli
mice
Immunity

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Kim, Dongwon ; Chen, Ruosi ; Sheu, Mary ; Kim, Noori ; Kim, Sooah ; Islam, Nasif ; Wier, Eric M. ; Wang, Gaofeng ; Li, Ang ; Park, Angela ; Son, Wooyang ; Evans, Benjamin ; Yu, Victoria ; Prizmic, Vicky P. ; Oh, Eugene ; Wang, Zixiao ; Yu, Jianshi ; Huang, Weiliang ; Archer, Nathan K. ; Hu, Zhiqi ; Clemetson, Nashay ; Nelson, Amanda ; Chien, Anna ; Okoye, Ginette A. ; Miller, Lloyd S. ; Ghiaur, Gabriel ; Kang, Sewon ; Jones, Jace W. ; Kane, Maureen A. ; Garza, Luis A. / Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3. In: Nature communications. 2019 ; Vol. 10, No. 1.
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abstract = "How developmental programs reactivate in regeneration is a fundamental question in biology. We addressed this question through the study of Wound Induced Hair follicle Neogenesis (WIHN), an adult organogenesis model where stem cells regenerate de novo hair follicles following deep wounding. The exact mechanism is uncertain. Here we show that self-noncoding dsRNA activates the anti-viral receptor toll like receptor 3 (TLR3) to induce intrinsic retinoic acid (RA) synthesis in a pattern that predicts new hair follicle formation after wounding in mice. Additionally, in humans, rejuvenation lasers induce gene expression signatures for dsRNA and RA, with measurable increases in intrinsic RA synthesis. These results demonstrate a potent stimulus for RA synthesis by non-coding dsRNA, relevant to their broad functions in development and immunity.",
author = "Dongwon Kim and Ruosi Chen and Mary Sheu and Noori Kim and Sooah Kim and Nasif Islam and Wier, {Eric M.} and Gaofeng Wang and Ang Li and Angela Park and Wooyang Son and Benjamin Evans and Victoria Yu and Prizmic, {Vicky P.} and Eugene Oh and Zixiao Wang and Jianshi Yu and Weiliang Huang and Archer, {Nathan K.} and Zhiqi Hu and Nashay Clemetson and Amanda Nelson and Anna Chien and Okoye, {Ginette A.} and Miller, {Lloyd S.} and Gabriel Ghiaur and Sewon Kang and Jones, {Jace W.} and Kane, {Maureen A.} and Garza, {Luis A.}",
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Kim, D, Chen, R, Sheu, M, Kim, N, Kim, S, Islam, N, Wier, EM, Wang, G, Li, A, Park, A, Son, W, Evans, B, Yu, V, Prizmic, VP, Oh, E, Wang, Z, Yu, J, Huang, W, Archer, NK, Hu, Z, Clemetson, N, Nelson, A, Chien, A, Okoye, GA, Miller, LS, Ghiaur, G, Kang, S, Jones, JW, Kane, MA & Garza, LA 2019, 'Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3', Nature communications, vol. 10, no. 1, 2811. https://doi.org/10.1038/s41467-019-10811-y

Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3. / Kim, Dongwon; Chen, Ruosi; Sheu, Mary; Kim, Noori; Kim, Sooah; Islam, Nasif; Wier, Eric M.; Wang, Gaofeng; Li, Ang; Park, Angela; Son, Wooyang; Evans, Benjamin; Yu, Victoria; Prizmic, Vicky P.; Oh, Eugene; Wang, Zixiao; Yu, Jianshi; Huang, Weiliang; Archer, Nathan K.; Hu, Zhiqi; Clemetson, Nashay; Nelson, Amanda; Chien, Anna; Okoye, Ginette A.; Miller, Lloyd S.; Ghiaur, Gabriel; Kang, Sewon; Jones, Jace W.; Kane, Maureen A.; Garza, Luis A.

In: Nature communications, Vol. 10, No. 1, 2811, 01.12.2019.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Noncoding dsRNA induces retinoic acid synthesis to stimulate hair follicle regeneration via TLR3

AU - Kim, Dongwon

AU - Chen, Ruosi

AU - Sheu, Mary

AU - Kim, Noori

AU - Kim, Sooah

AU - Islam, Nasif

AU - Wier, Eric M.

AU - Wang, Gaofeng

AU - Li, Ang

AU - Park, Angela

AU - Son, Wooyang

AU - Evans, Benjamin

AU - Yu, Victoria

AU - Prizmic, Vicky P.

AU - Oh, Eugene

AU - Wang, Zixiao

AU - Yu, Jianshi

AU - Huang, Weiliang

AU - Archer, Nathan K.

AU - Hu, Zhiqi

AU - Clemetson, Nashay

AU - Nelson, Amanda

AU - Chien, Anna

AU - Okoye, Ginette A.

AU - Miller, Lloyd S.

AU - Ghiaur, Gabriel

AU - Kang, Sewon

AU - Jones, Jace W.

AU - Kane, Maureen A.

AU - Garza, Luis A.

PY - 2019/12/1

Y1 - 2019/12/1

N2 - How developmental programs reactivate in regeneration is a fundamental question in biology. We addressed this question through the study of Wound Induced Hair follicle Neogenesis (WIHN), an adult organogenesis model where stem cells regenerate de novo hair follicles following deep wounding. The exact mechanism is uncertain. Here we show that self-noncoding dsRNA activates the anti-viral receptor toll like receptor 3 (TLR3) to induce intrinsic retinoic acid (RA) synthesis in a pattern that predicts new hair follicle formation after wounding in mice. Additionally, in humans, rejuvenation lasers induce gene expression signatures for dsRNA and RA, with measurable increases in intrinsic RA synthesis. These results demonstrate a potent stimulus for RA synthesis by non-coding dsRNA, relevant to their broad functions in development and immunity.

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