Noninvasive quantification of human nucleus pulposus pressure with use of T1p-weighted magnetic resonance imaging

An M. Nguyen, Wade Johannessen, Jonathon H. Yoder, Andrew J. Wheaton, Edward Vresilovic, Arijitt Borthakur, Dawn M. Elliott

Research output: Contribution to journalArticle

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Abstract

Background: Early diagnosis is a challenge in the treatment of degenerative disc disease. A noninvasive biomarker detecting functional mechanics of the disc is needed. T1ρ-weighted imaging, a spin-lock magnetic resonance imaging technique, has shown promise for meeting this need in in vivo studies demonstrating the clinical feasibility of evaluating both intervertebral discs and articular cartilage. The objectives of the present study were (1) to quantitatively determine the relationship between T1ρ relaxation time and measures of nucleus pulposus mechanics, and (2) to evaluate whether the quantitative relationship of T1ρ relaxation time with the degenerative grade and glycosaminoglycan content extend to more severe degeneration. It was hypothesized that the isometric swelling pressure and compressive modulus would be directly correlated with the T1ρ relaxation time and the apparent permeability would be inversely correlated with the T1ρ relaxation time. Methods: Eight cadaver human lumbar spines were imaged to measure T1ρ relaxation times. The nucleus pulposus tissue from the L1 disc through the S1 disc was tested in confined compression to determine the swelling pressure, compressive modulus, and permeability. The glycosaminoglycan and water contents were measured in adjacent tissue. Linear regression analyses were performed to examine the correlation between the T1ρ relaxation time and the other measured variables. Mechanical properties and biochemical content were evaluated for differences associated with degeneration. Results: A positive linear correlation was observed between the T1ρ relaxation time on the images of the nucleus pulposus and the swelling pressure (r = 0.59), glycosaminoglycan content per dry weight (r = 0.69), glycosaminoglycan per wet weight (r = 0.49), and water content (r = 0.53). No significant correlations were observed between the T1ρ relaxation time and the modulus or permeability. Similarly, the T1ρ relaxation time, swelling pressure, glycosaminoglycan content per dry weight, and water content were significantly altered with degeneration, whereas the modulus and permeability were not. Conclusions: T1ρ-weighted magnetic resonance imaging has a strong potential as a quantitative biomarker of the mechanical function of the nucleus pulposus and of disc degeneration. Clinical Relevance: Several in vivo studies have previously demonstrated the clinical feasibility of using Tip-weighted imaging to evaluate both intervertebral discs and articular cartilage. Its application for the diagnosis of disc degeneration looks promising.

Original languageEnglish (US)
Pages (from-to)796-802
Number of pages7
JournalJournal of Bone and Joint Surgery - Series A
Volume90
Issue number4
DOIs
StatePublished - Jan 1 2008

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Magnetic Resonance Imaging
Pressure
Glycosaminoglycans
Permeability
Intervertebral Disc Degeneration
Intervertebral Disc
Articular Cartilage
Mechanics
Weights and Measures
Water
Biomarkers
Nucleus Pulposus
Cadaver
Early Diagnosis
Linear Models
Spine
Regression Analysis

All Science Journal Classification (ASJC) codes

  • Surgery
  • Orthopedics and Sports Medicine

Cite this

Nguyen, A. M., Johannessen, W., Yoder, J. H., Wheaton, A. J., Vresilovic, E., Borthakur, A., & Elliott, D. M. (2008). Noninvasive quantification of human nucleus pulposus pressure with use of T1p-weighted magnetic resonance imaging. Journal of Bone and Joint Surgery - Series A, 90(4), 796-802. https://doi.org/10.2106/JBJS.G.00667
Nguyen, An M. ; Johannessen, Wade ; Yoder, Jonathon H. ; Wheaton, Andrew J. ; Vresilovic, Edward ; Borthakur, Arijitt ; Elliott, Dawn M. / Noninvasive quantification of human nucleus pulposus pressure with use of T1p-weighted magnetic resonance imaging. In: Journal of Bone and Joint Surgery - Series A. 2008 ; Vol. 90, No. 4. pp. 796-802.
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title = "Noninvasive quantification of human nucleus pulposus pressure with use of T1p-weighted magnetic resonance imaging",
abstract = "Background: Early diagnosis is a challenge in the treatment of degenerative disc disease. A noninvasive biomarker detecting functional mechanics of the disc is needed. T1ρ-weighted imaging, a spin-lock magnetic resonance imaging technique, has shown promise for meeting this need in in vivo studies demonstrating the clinical feasibility of evaluating both intervertebral discs and articular cartilage. The objectives of the present study were (1) to quantitatively determine the relationship between T1ρ relaxation time and measures of nucleus pulposus mechanics, and (2) to evaluate whether the quantitative relationship of T1ρ relaxation time with the degenerative grade and glycosaminoglycan content extend to more severe degeneration. It was hypothesized that the isometric swelling pressure and compressive modulus would be directly correlated with the T1ρ relaxation time and the apparent permeability would be inversely correlated with the T1ρ relaxation time. Methods: Eight cadaver human lumbar spines were imaged to measure T1ρ relaxation times. The nucleus pulposus tissue from the L1 disc through the S1 disc was tested in confined compression to determine the swelling pressure, compressive modulus, and permeability. The glycosaminoglycan and water contents were measured in adjacent tissue. Linear regression analyses were performed to examine the correlation between the T1ρ relaxation time and the other measured variables. Mechanical properties and biochemical content were evaluated for differences associated with degeneration. Results: A positive linear correlation was observed between the T1ρ relaxation time on the images of the nucleus pulposus and the swelling pressure (r = 0.59), glycosaminoglycan content per dry weight (r = 0.69), glycosaminoglycan per wet weight (r = 0.49), and water content (r = 0.53). No significant correlations were observed between the T1ρ relaxation time and the modulus or permeability. Similarly, the T1ρ relaxation time, swelling pressure, glycosaminoglycan content per dry weight, and water content were significantly altered with degeneration, whereas the modulus and permeability were not. Conclusions: T1ρ-weighted magnetic resonance imaging has a strong potential as a quantitative biomarker of the mechanical function of the nucleus pulposus and of disc degeneration. Clinical Relevance: Several in vivo studies have previously demonstrated the clinical feasibility of using Tip-weighted imaging to evaluate both intervertebral discs and articular cartilage. Its application for the diagnosis of disc degeneration looks promising.",
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Nguyen, AM, Johannessen, W, Yoder, JH, Wheaton, AJ, Vresilovic, E, Borthakur, A & Elliott, DM 2008, 'Noninvasive quantification of human nucleus pulposus pressure with use of T1p-weighted magnetic resonance imaging', Journal of Bone and Joint Surgery - Series A, vol. 90, no. 4, pp. 796-802. https://doi.org/10.2106/JBJS.G.00667

Noninvasive quantification of human nucleus pulposus pressure with use of T1p-weighted magnetic resonance imaging. / Nguyen, An M.; Johannessen, Wade; Yoder, Jonathon H.; Wheaton, Andrew J.; Vresilovic, Edward; Borthakur, Arijitt; Elliott, Dawn M.

In: Journal of Bone and Joint Surgery - Series A, Vol. 90, No. 4, 01.01.2008, p. 796-802.

Research output: Contribution to journalArticle

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T1 - Noninvasive quantification of human nucleus pulposus pressure with use of T1p-weighted magnetic resonance imaging

AU - Nguyen, An M.

AU - Johannessen, Wade

AU - Yoder, Jonathon H.

AU - Wheaton, Andrew J.

AU - Vresilovic, Edward

AU - Borthakur, Arijitt

AU - Elliott, Dawn M.

PY - 2008/1/1

Y1 - 2008/1/1

N2 - Background: Early diagnosis is a challenge in the treatment of degenerative disc disease. A noninvasive biomarker detecting functional mechanics of the disc is needed. T1ρ-weighted imaging, a spin-lock magnetic resonance imaging technique, has shown promise for meeting this need in in vivo studies demonstrating the clinical feasibility of evaluating both intervertebral discs and articular cartilage. The objectives of the present study were (1) to quantitatively determine the relationship between T1ρ relaxation time and measures of nucleus pulposus mechanics, and (2) to evaluate whether the quantitative relationship of T1ρ relaxation time with the degenerative grade and glycosaminoglycan content extend to more severe degeneration. It was hypothesized that the isometric swelling pressure and compressive modulus would be directly correlated with the T1ρ relaxation time and the apparent permeability would be inversely correlated with the T1ρ relaxation time. Methods: Eight cadaver human lumbar spines were imaged to measure T1ρ relaxation times. The nucleus pulposus tissue from the L1 disc through the S1 disc was tested in confined compression to determine the swelling pressure, compressive modulus, and permeability. The glycosaminoglycan and water contents were measured in adjacent tissue. Linear regression analyses were performed to examine the correlation between the T1ρ relaxation time and the other measured variables. Mechanical properties and biochemical content were evaluated for differences associated with degeneration. Results: A positive linear correlation was observed between the T1ρ relaxation time on the images of the nucleus pulposus and the swelling pressure (r = 0.59), glycosaminoglycan content per dry weight (r = 0.69), glycosaminoglycan per wet weight (r = 0.49), and water content (r = 0.53). No significant correlations were observed between the T1ρ relaxation time and the modulus or permeability. Similarly, the T1ρ relaxation time, swelling pressure, glycosaminoglycan content per dry weight, and water content were significantly altered with degeneration, whereas the modulus and permeability were not. Conclusions: T1ρ-weighted magnetic resonance imaging has a strong potential as a quantitative biomarker of the mechanical function of the nucleus pulposus and of disc degeneration. Clinical Relevance: Several in vivo studies have previously demonstrated the clinical feasibility of using Tip-weighted imaging to evaluate both intervertebral discs and articular cartilage. Its application for the diagnosis of disc degeneration looks promising.

AB - Background: Early diagnosis is a challenge in the treatment of degenerative disc disease. A noninvasive biomarker detecting functional mechanics of the disc is needed. T1ρ-weighted imaging, a spin-lock magnetic resonance imaging technique, has shown promise for meeting this need in in vivo studies demonstrating the clinical feasibility of evaluating both intervertebral discs and articular cartilage. The objectives of the present study were (1) to quantitatively determine the relationship between T1ρ relaxation time and measures of nucleus pulposus mechanics, and (2) to evaluate whether the quantitative relationship of T1ρ relaxation time with the degenerative grade and glycosaminoglycan content extend to more severe degeneration. It was hypothesized that the isometric swelling pressure and compressive modulus would be directly correlated with the T1ρ relaxation time and the apparent permeability would be inversely correlated with the T1ρ relaxation time. Methods: Eight cadaver human lumbar spines were imaged to measure T1ρ relaxation times. The nucleus pulposus tissue from the L1 disc through the S1 disc was tested in confined compression to determine the swelling pressure, compressive modulus, and permeability. The glycosaminoglycan and water contents were measured in adjacent tissue. Linear regression analyses were performed to examine the correlation between the T1ρ relaxation time and the other measured variables. Mechanical properties and biochemical content were evaluated for differences associated with degeneration. Results: A positive linear correlation was observed between the T1ρ relaxation time on the images of the nucleus pulposus and the swelling pressure (r = 0.59), glycosaminoglycan content per dry weight (r = 0.69), glycosaminoglycan per wet weight (r = 0.49), and water content (r = 0.53). No significant correlations were observed between the T1ρ relaxation time and the modulus or permeability. Similarly, the T1ρ relaxation time, swelling pressure, glycosaminoglycan content per dry weight, and water content were significantly altered with degeneration, whereas the modulus and permeability were not. Conclusions: T1ρ-weighted magnetic resonance imaging has a strong potential as a quantitative biomarker of the mechanical function of the nucleus pulposus and of disc degeneration. Clinical Relevance: Several in vivo studies have previously demonstrated the clinical feasibility of using Tip-weighted imaging to evaluate both intervertebral discs and articular cartilage. Its application for the diagnosis of disc degeneration looks promising.

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