Noninvasive ultrasonic glucose sensing with large pigs (∼200 pounds) using a lightweight cymbal transducer array and biosensors

Eun Joo Park, Jacob Robert Werner, Joshua Beebe, Samantha Chan, Nadine Barrie Smith

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: To prevent complications in diabetes, the proper management of blood glucose levels is essential. Since conventional glucose meters require pricking fingers or other areas of the skin, a noninvasive method for monitoring blood glucose levels is desired. Using a lightweight cymbal transducer array, this study was conducted to noninvasively determine the glucose levels of pigs having a similar size to humans. Method: In vivo experiments using eight pigs (∼200 pounds) were performed in five groups. A cymbal array with four biosensors was attached to the axillary area of the pig. The array was operated at 20 kHz at special peak-temporal peak intensity (Isptp) equal to 50 or 100 mW/cm2 for 5, 10, or 20 minutes. After the ultrasound exposure, glucose concentrations of the interstitial fluid were determined using biosensors. For comparison, glucose levels of blood samples collected from the ear vein were measured by a commercial glucose meter. Result: In comparison, glucose levels determined by a cymbal array and biosensor system were close to those measured by a glucose meter. After a 20-minute ultrasound exposure at Isptp = 100 mW/cm2, the average glucose level determined by the ultrasound system was 175 ± 7 mg/dl, which is close to 166 ± 5 mg/dl measured by the glucose meter. Conclusion: Results indicate the feasibility of using a cymbal array for noninvasive glucose sensing on pigs having a similar size to humans. Further studies on the ultrasound conditions, such as frequency, intensity, and exposure time, will be continued for effective glucose sensing.

Original languageEnglish (US)
Pages (from-to)517-523
Number of pages7
JournalJournal of Diabetes Science and Technology
Volume3
Issue number3
DOIs
StatePublished - Jan 1 2009

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Biosensing Techniques
Transducers
Biosensors
Ultrasonics
Glucose
Swine
Blood Glucose
Blood
Extracellular Fluid
Diabetes Complications
Medical problems
Fingers
Ear
Veins
Skin

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Bioengineering
  • Biomedical Engineering

Cite this

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abstract = "Background: To prevent complications in diabetes, the proper management of blood glucose levels is essential. Since conventional glucose meters require pricking fingers or other areas of the skin, a noninvasive method for monitoring blood glucose levels is desired. Using a lightweight cymbal transducer array, this study was conducted to noninvasively determine the glucose levels of pigs having a similar size to humans. Method: In vivo experiments using eight pigs (∼200 pounds) were performed in five groups. A cymbal array with four biosensors was attached to the axillary area of the pig. The array was operated at 20 kHz at special peak-temporal peak intensity (Isptp) equal to 50 or 100 mW/cm2 for 5, 10, or 20 minutes. After the ultrasound exposure, glucose concentrations of the interstitial fluid were determined using biosensors. For comparison, glucose levels of blood samples collected from the ear vein were measured by a commercial glucose meter. Result: In comparison, glucose levels determined by a cymbal array and biosensor system were close to those measured by a glucose meter. After a 20-minute ultrasound exposure at Isptp = 100 mW/cm2, the average glucose level determined by the ultrasound system was 175 ± 7 mg/dl, which is close to 166 ± 5 mg/dl measured by the glucose meter. Conclusion: Results indicate the feasibility of using a cymbal array for noninvasive glucose sensing on pigs having a similar size to humans. Further studies on the ultrasound conditions, such as frequency, intensity, and exposure time, will be continued for effective glucose sensing.",
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Noninvasive ultrasonic glucose sensing with large pigs (∼200 pounds) using a lightweight cymbal transducer array and biosensors. / Park, Eun Joo; Werner, Jacob Robert; Beebe, Joshua; Chan, Samantha; Smith, Nadine Barrie.

In: Journal of Diabetes Science and Technology, Vol. 3, No. 3, 01.01.2009, p. 517-523.

Research output: Contribution to journalArticle

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N2 - Background: To prevent complications in diabetes, the proper management of blood glucose levels is essential. Since conventional glucose meters require pricking fingers or other areas of the skin, a noninvasive method for monitoring blood glucose levels is desired. Using a lightweight cymbal transducer array, this study was conducted to noninvasively determine the glucose levels of pigs having a similar size to humans. Method: In vivo experiments using eight pigs (∼200 pounds) were performed in five groups. A cymbal array with four biosensors was attached to the axillary area of the pig. The array was operated at 20 kHz at special peak-temporal peak intensity (Isptp) equal to 50 or 100 mW/cm2 for 5, 10, or 20 minutes. After the ultrasound exposure, glucose concentrations of the interstitial fluid were determined using biosensors. For comparison, glucose levels of blood samples collected from the ear vein were measured by a commercial glucose meter. Result: In comparison, glucose levels determined by a cymbal array and biosensor system were close to those measured by a glucose meter. After a 20-minute ultrasound exposure at Isptp = 100 mW/cm2, the average glucose level determined by the ultrasound system was 175 ± 7 mg/dl, which is close to 166 ± 5 mg/dl measured by the glucose meter. Conclusion: Results indicate the feasibility of using a cymbal array for noninvasive glucose sensing on pigs having a similar size to humans. Further studies on the ultrasound conditions, such as frequency, intensity, and exposure time, will be continued for effective glucose sensing.

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