Nonlinear optical image processing with bacteriorhodopsin polymer films

Chandra S. Yelleswarapu, Pengfei Wu, Sri-Rajasekhar Kothapalli, D. V.G.L.N. Rao

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Real-time medical image processing through nonlinear optical Fourier filtering and transient Fourier holography is demonstrated using bio-organic polymer films of Bacteriorhodopsin (bR). In nonlinear Fourier filtering, the photo-controlled light modulation characteristics of bR films are exploited for early detection of microcalcifications in analog (screen film) as well as digital mammograms. bR films are well known for light modulation between the two states: the initial stable B state with broad absorption band with maximum at 570 nm and the relatively long lived M state with absorption maximum at 412 nm. The spatial frequency information carried by a blue probe beam is selectively manipulated in the bR film by changing the position and intensity of a yellow control beam. In transient Fourier holography, photoisomerizative gratings are recorded and reconstructed in bR films. The laser output from an Ar-Kr ion is expanded and split into two beams. One of them, the object beam is Fourier transformed by a lens on to the bR film placed at the Fourier plane. The second beam (reference beam) overlaps the Fourier transform of the object beam on the bR film thereby recordi00000000ng a Fourier hologram. When the object beam is blocked, the reference beam performs the reconstruction of the recorded Fourier hologram. The filtered spectrum is inverse Fourier transformed on to the CCD camera. The image processing is based on the fact that the desired spatial frequency band is recorded with optimum diffraction efficiency and matching the reference beam intensity to their intensity in the Fourier spectrum. A novel feature of the technique is the ability to transient display selected spatial frequencies in the reconstructing process which enables the radiologist to study the features of interest in time scale. Both the techniques are applied to filter out low spatial frequencies corresponding to soft dense breast tissue and display only high spatial frequencies corresponding to microcalcifications in clinical screen film mammograms. The results offer useful information to radiologists for early detection of breast cancer.

Original languageEnglish (US)
Pages (from-to)273-294
Number of pages22
JournalMolecular crystals and liquid crystals
Volume446
DOIs
StatePublished - Feb 24 2006

Fingerprint

Bacteriorhodopsins
Polymer films
image processing
Image processing
polymers
Light modulation
Holography
Holograms
light modulation
breast
holography
Medical image processing
Diffraction efficiency
Organic polymers
Diffraction gratings
CCD cameras
Frequency bands
Absorption spectra
Lenses
laser outputs

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

Cite this

Yelleswarapu, Chandra S. ; Wu, Pengfei ; Kothapalli, Sri-Rajasekhar ; Rao, D. V.G.L.N. / Nonlinear optical image processing with bacteriorhodopsin polymer films. In: Molecular crystals and liquid crystals. 2006 ; Vol. 446. pp. 273-294.
@article{391c2c42d38d4450b055e035b894d6c1,
title = "Nonlinear optical image processing with bacteriorhodopsin polymer films",
abstract = "Real-time medical image processing through nonlinear optical Fourier filtering and transient Fourier holography is demonstrated using bio-organic polymer films of Bacteriorhodopsin (bR). In nonlinear Fourier filtering, the photo-controlled light modulation characteristics of bR films are exploited for early detection of microcalcifications in analog (screen film) as well as digital mammograms. bR films are well known for light modulation between the two states: the initial stable B state with broad absorption band with maximum at 570 nm and the relatively long lived M state with absorption maximum at 412 nm. The spatial frequency information carried by a blue probe beam is selectively manipulated in the bR film by changing the position and intensity of a yellow control beam. In transient Fourier holography, photoisomerizative gratings are recorded and reconstructed in bR films. The laser output from an Ar-Kr ion is expanded and split into two beams. One of them, the object beam is Fourier transformed by a lens on to the bR film placed at the Fourier plane. The second beam (reference beam) overlaps the Fourier transform of the object beam on the bR film thereby recordi00000000ng a Fourier hologram. When the object beam is blocked, the reference beam performs the reconstruction of the recorded Fourier hologram. The filtered spectrum is inverse Fourier transformed on to the CCD camera. The image processing is based on the fact that the desired spatial frequency band is recorded with optimum diffraction efficiency and matching the reference beam intensity to their intensity in the Fourier spectrum. A novel feature of the technique is the ability to transient display selected spatial frequencies in the reconstructing process which enables the radiologist to study the features of interest in time scale. Both the techniques are applied to filter out low spatial frequencies corresponding to soft dense breast tissue and display only high spatial frequencies corresponding to microcalcifications in clinical screen film mammograms. The results offer useful information to radiologists for early detection of breast cancer.",
author = "Yelleswarapu, {Chandra S.} and Pengfei Wu and Sri-Rajasekhar Kothapalli and Rao, {D. V.G.L.N.}",
year = "2006",
month = "2",
day = "24",
doi = "10.1080/15421400500379756",
language = "English (US)",
volume = "446",
pages = "273--294",
journal = "Molecular Crystals and Liquid Crystals",
issn = "1542-1406",
publisher = "Taylor and Francis Ltd.",

}

Nonlinear optical image processing with bacteriorhodopsin polymer films. / Yelleswarapu, Chandra S.; Wu, Pengfei; Kothapalli, Sri-Rajasekhar; Rao, D. V.G.L.N.

In: Molecular crystals and liquid crystals, Vol. 446, 24.02.2006, p. 273-294.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Nonlinear optical image processing with bacteriorhodopsin polymer films

AU - Yelleswarapu, Chandra S.

AU - Wu, Pengfei

AU - Kothapalli, Sri-Rajasekhar

AU - Rao, D. V.G.L.N.

PY - 2006/2/24

Y1 - 2006/2/24

N2 - Real-time medical image processing through nonlinear optical Fourier filtering and transient Fourier holography is demonstrated using bio-organic polymer films of Bacteriorhodopsin (bR). In nonlinear Fourier filtering, the photo-controlled light modulation characteristics of bR films are exploited for early detection of microcalcifications in analog (screen film) as well as digital mammograms. bR films are well known for light modulation between the two states: the initial stable B state with broad absorption band with maximum at 570 nm and the relatively long lived M state with absorption maximum at 412 nm. The spatial frequency information carried by a blue probe beam is selectively manipulated in the bR film by changing the position and intensity of a yellow control beam. In transient Fourier holography, photoisomerizative gratings are recorded and reconstructed in bR films. The laser output from an Ar-Kr ion is expanded and split into two beams. One of them, the object beam is Fourier transformed by a lens on to the bR film placed at the Fourier plane. The second beam (reference beam) overlaps the Fourier transform of the object beam on the bR film thereby recordi00000000ng a Fourier hologram. When the object beam is blocked, the reference beam performs the reconstruction of the recorded Fourier hologram. The filtered spectrum is inverse Fourier transformed on to the CCD camera. The image processing is based on the fact that the desired spatial frequency band is recorded with optimum diffraction efficiency and matching the reference beam intensity to their intensity in the Fourier spectrum. A novel feature of the technique is the ability to transient display selected spatial frequencies in the reconstructing process which enables the radiologist to study the features of interest in time scale. Both the techniques are applied to filter out low spatial frequencies corresponding to soft dense breast tissue and display only high spatial frequencies corresponding to microcalcifications in clinical screen film mammograms. The results offer useful information to radiologists for early detection of breast cancer.

AB - Real-time medical image processing through nonlinear optical Fourier filtering and transient Fourier holography is demonstrated using bio-organic polymer films of Bacteriorhodopsin (bR). In nonlinear Fourier filtering, the photo-controlled light modulation characteristics of bR films are exploited for early detection of microcalcifications in analog (screen film) as well as digital mammograms. bR films are well known for light modulation between the two states: the initial stable B state with broad absorption band with maximum at 570 nm and the relatively long lived M state with absorption maximum at 412 nm. The spatial frequency information carried by a blue probe beam is selectively manipulated in the bR film by changing the position and intensity of a yellow control beam. In transient Fourier holography, photoisomerizative gratings are recorded and reconstructed in bR films. The laser output from an Ar-Kr ion is expanded and split into two beams. One of them, the object beam is Fourier transformed by a lens on to the bR film placed at the Fourier plane. The second beam (reference beam) overlaps the Fourier transform of the object beam on the bR film thereby recordi00000000ng a Fourier hologram. When the object beam is blocked, the reference beam performs the reconstruction of the recorded Fourier hologram. The filtered spectrum is inverse Fourier transformed on to the CCD camera. The image processing is based on the fact that the desired spatial frequency band is recorded with optimum diffraction efficiency and matching the reference beam intensity to their intensity in the Fourier spectrum. A novel feature of the technique is the ability to transient display selected spatial frequencies in the reconstructing process which enables the radiologist to study the features of interest in time scale. Both the techniques are applied to filter out low spatial frequencies corresponding to soft dense breast tissue and display only high spatial frequencies corresponding to microcalcifications in clinical screen film mammograms. The results offer useful information to radiologists for early detection of breast cancer.

UR - http://www.scopus.com/inward/record.url?scp=32944477299&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=32944477299&partnerID=8YFLogxK

U2 - 10.1080/15421400500379756

DO - 10.1080/15421400500379756

M3 - Article

VL - 446

SP - 273

EP - 294

JO - Molecular Crystals and Liquid Crystals

JF - Molecular Crystals and Liquid Crystals

SN - 1542-1406

ER -